C反应蛋白与恶性肿瘤并发急性下肢深静脉血栓形成及预后的关系  

Implication of C-reactive protein in development and prognosis of acute lower limb deep venous thrombosis complicated by malignant tumor

作　　者：朱其聪[1] 王亚辉[1] 陈尼卡[1] 陈路明[1] 张正义[1] 徐斌[1] 

机构地区：[1]海口市解放军第一八七医院内三科,571106

出　　处：《肿瘤研究与临床》2011年第12期829-831,共3页Cancer Research and Clinic

摘　　要：目的探讨血清C反应蛋白（CRP）对恶性肿瘤并发急性下肢深静脉血栓（DVT）形成及疗效的影响。方法选择恶性肿瘤并发急性下肢DVT患者34例（观察组）、同期创伤或手术后并发下肢DVT患者34例（病例对照组）、同期健康体检者34名（健康对照组）。观察组和病例对照组均给予溶栓、抗凝等常规治疗，检测两组治疗前、治疗14d血清CRP质量浓度，比较两组治疗后下肢深静脉再通情况和疗效。结果治疗前观察组血清CRP质量浓度为（47．72±29．88）mg／L，显著高于病例对照组和健康对照组[（30．04±15．84）mg／L、（6．19±2．99）mg／LI（F=38．444，P〈0．01）；治疗14d后观察组和病例对照组CRP质量浓度均显著下降，分别为（32．77±19．68）mg／L、（7．76±7．52）mg／L，但观察组CRP质量浓度仍显著高于病例对照组和健康对照组（F：50．087，P〈0．01），而病例对照组与健康对照组血清CRP质量浓度差异无统计学意义（F=1．277，P=0．263）。治疗后观察组肢体再通率为67．65％（23／34），显著低于病例对照组的94．12％（32／34）（χ2=7．731，P=0．021）；治疗对DVT的有效率观察组为76．47％（26／34），显著低于病例对照组的97．06％（33／34）（χ2=6．969，P=0．031）。结论CRP与恶性肿瘤并发的下肢DVT发生、发展及预后密切相关。Objective To investigate the implication of C-reactive protein in development and prognosis of acute lower limb deep venous thrombosis （DVT） complicated by malignant tumor. Methods 34 patients with acute lower limb DVT complicated by malignant tumor （observation group）, 34 patients with acute lower limb DVT complicated by operation or wound （case control group） and 34 normal volunteers （normal control group） were included in this study. The observation group and case control group were treated with conventional therapy such as thrombolysis and antieoagulation. The serum concentrations of CRP before treatment and 14 days after treatment were detected. Recanalization of lower limb DVT and therapeutic efficacy were compared between observation group and case control group. Results The serum concentrations of CRP in observation group before treatment were significantly higher than those in case control group and normal control group [（47.72±29.88） mg/L vs （30.04±15.84） mg/L and （6.19±2.99） rag/L, F = 38.444, P 〈 0.01]. At the 14th day of post-treatment, the serum CRP concentrations in observation group and case control group were significantly lower than those before treatment （ip 〈0.05）. At the 14th day of post-treatment, the CRP concentrations of observation group and case control groups were significantly decreased, although those of observation group were still significantly higher than those of case control group and normal control [（32.77±19.68） mg/L vs （7.76±7.52） mg/L and （6.19±2.99） rag/L, F = 50.087, P 〈 0.01]. However, there was no significant difference between case control group and normal control group on the 14th day of post-treatment （F = 1.277, P = 0.263）. The recanalization rate of observation group at the 14th day of post-treatment were significantly lower than those in case control group （χ2= 7.731, P = 0.021）. The therapeutic effect rate of observation group at the 14th day of post-treatment were also significantly lower than those

关 键 词：C反应蛋白质 静脉血栓形成 治疗结果 

分 类 号：R730.4[医药卫生—肿瘤]