新疆维吾尔自治区少数民族女性三阴性乳腺癌临床病理特点及生存情况分析  

Analysis of clinicopathological characteristics and survival of minority female patients with triple negative breast cancer in Xinjiang Uygur Autonomous Region

作　　者：胡军[1] 吴克雄[1] 朱海鹏[1] 高丽霞[1] 

机构地区：[1]新疆维吾尔自治区克拉玛依市中心医院血液肿瘤科,8340000

出　　处：《肿瘤研究与临床》2011年第12期836-838,共3页Cancer Research and Clinic

摘　　要：目的研究新疆维吾尔自治区少数民族女性三阴性乳腺癌的临床病理特点及其生存情况。方法回顾性分析2001年1月至2005年12月诊治的48例新疆维吾尔自治区少数民族女性乳腺癌患者术后资料，经免疫组织化学检测雌激素受体（ER）、孕激素受体（PR）和人类表皮生长因子受体-2（Her-2）均阴性，分析其发病年龄、肿瘤大小、病理类型、淋巴结转移、术后治疗情况及肿瘤复发生存情况。结果48例三阴性乳腺癌（TNBC）患者中位发病年龄47岁，浸润性导管癌41例（85．4％），组织学分级多为Ⅱ、Ⅲ级。27例（56．2％）首诊时有淋巴结转移，Ⅱ、Ⅲ期患者39例（833％）。获随访的46例患者均接受了术后辅助治疗。5年无病生存率及总生存率分别为43．5％（20／46）及52．2％（24／46），淋巴结阳性患者5年总生存率仅为38．5％（10／26）。结论新疆维吾尔自治区少数民族女性TNBC首诊时淋巴结转移率高，易发生远处转移，发病情况与中国其他民族相当，总生存率较汉族人群偏低，淋巴结阳性患者生存期较短。Objective To analyze the clinicopathologic characteristics and survival of ethnic minority female patients with triple negative breast cancer （TNBC） from Xinjiang Uygur Autonomous Region. Methods The clinicopathological characteristics, including age at diagnosis, size of tumor mass, lymphnode involvement, adjuvant therapy, recurrence of disease and survival of patient, of 48 ethnic minority patient cases with TNBC negative for estrogen receptor （ER）, progesterone receptor （PR） and human epidermal growth factor receptor-2 （Her-2） were analyzed, whom were treated in our hospital from January 2001 to December 2005, including age at diagnosis, size of tumor mass, lymph node involvement, adjuvant therapy, recurrence of disease and survival of patients. Results Of the 48 patients, median age was 47 years, and 83.3 % （39 cases） of patients had stage Ⅱ or Ⅲ disease. The majority （85.4 %, 41 cases） of pathological types were grade Ⅱ or Ⅲ invasive ductal carcinomas, and lymph node involvement was detected in 56.2 % （27 cases） of these patients at initial diagnosis. 46 patients were followed and had adjuvant therapy. Tumor-free survival and overall survival at 5 years were 43.5 % （20/46） and 52.2 % （24/46）, respectively. Patients with lymph node involved had only 38.5 % （10/46） of overall survival at 5 years. Conclusion The incidence of triple negative breast cancer of female patients in Xinjiang multiple minority groups is similar to domestic study, and the rates of over all survival is lower than that in Han Chinese patients. The female patients with TNBC in Xinjiang Uygur Autonomous Region multiple minority groups showed higher lymph node involvement at initial diagnosis and more distal metastasis. Patients with lymph node involved had poor survival.

关 键 词：新疆[维吾尔自治区] 乳腺肿瘤 临床 病理 生存分析 

分 类 号：R737.9[医药卫生—肿瘤]