microRNA与脑胶质瘤的相关性研究进展  

Research progress of relationship between microRNA and glioma

作　　者：刘越（综述）[1] 汪泱（审校）[1] 邓志锋（审校）[1] 

机构地区：[1]南昌大学第二附属医院神经外科,330006

出　　处：《肿瘤研究与临床》2011年第12期852-855,共4页Cancer Research and Clinic

基　　金：国家科技支撑计划（2008BA168806）;国家自然科学基金（30960396）

摘　　要：microRNA（miRNA）是一类内源性约21—25个核苷酸的非编码小RNA分子，在中枢神经系统中含量丰富。miRNA在神经系统的发育及可塑性中发挥重要作用，并且与神经系统有关疾病的发生发展密切相关。近年来研究表明miRNA表达失控与神经胶质瘤发生发展密切相关。现就miRNA在神经胶质瘤中作用的研究进展等方面作一概述。MicroRNA （miRNA）, an abundant class of small non-coding RNA, are abundant in the central nervous system where they play important roles in the neuronal development and plasticity. Moreover, the relationship between miRNA dysfunction and neurological diseases become more and more apparent. Recent studies show that the misregulated expression of miRNA out of control is closely related to the development of glioma. In this review we discussed the progress on the study of miRNA in Glioma.

关 键 词：微RNAS 神经胶质瘤 肿瘤标记 生物学 

分 类 号：R394.1[医药卫生—医学遗传学]