Self-assembly of lipids and nanoparticles in aqueous solution:Self-consistent field simulations  

作　　者：Weihua Xie Guangkui Xu Xiqiao Feng 

机构地区：[1]Institute of Biomechanics and Medical Engineering,Department of Engineering Mechanics,Tsinghua University,Beijing 100084,China

出　　处：《Theoretical & Applied Mechanics Letters》2012年第1期22-26,共5页力学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(10972121);the Ministry of Education (SRFDP 20090002110047);the 973 Program of MOST(2012CB934101)

摘　　要：Self-assembled nanostructures of lipids and nanoparticles hold great promise for applications in such fields as nanomedicine. This paper uses the self-consistent field theory to investigate the self-assembly behavior of lipid molecules and nanoparticles with different shapes in an aqueous solution. It is found that the lipid molecules can form monolayered and bilayered nanostructures around the nanopartieles with different shapes （e.g., triangular, square, hexagonal and octangular）. With decreasing the size of nanoparticles or increasing the number of polygon edges, the shape of lipid layers will approach an approximately spherical shape. These findings may help to predict and design novel drug delivery nanocarriers.Self-assembled nanostructures of lipids and nanoparticles hold great promise for applications in such fields as nanomedicine. This paper uses the self-consistent field theory to investigate the self-assembly behavior of lipid molecules and nanoparticles with different shapes in an aqueous solution. It is found that the lipid molecules can form monolayered and bilayered nanostructures around the nanopartieles with different shapes （e.g., triangular, square, hexagonal and octangular）. With decreasing the size of nanoparticles or increasing the number of polygon edges, the shape of lipid layers will approach an approximately spherical shape. These findings may help to predict and design novel drug delivery nanocarriers.

关 键 词：LIPOSOME NANOPARTICLE SELF-ASSEMBLY self-consistent field theory drug delivery 

分 类 号：O633[理学—高分子化学] TB383[理学—化学]