Yapl蛋白在前列腺癌中的表达及其临床病理学意义  

Expression of yes-associated protein 1 in prostate cancer and its clinicopatholoeical simliflcance

作　　者：胡晓勇[1] 徐月敏[1] 乔勇[1] 俞建军[1] 陈杰[2] 

机构地区：[1]上海交通大学附属第六人民医院泌尿外科,上海200233 [2]上海交通大学附属第六人民医院病理科,上海200233

出　　处：《中华实验外科杂志》2012年第2期280-281,F0003,F0004,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金资助项目（30801150）

摘　　要：目的探讨Yapl蛋白在前列腺癌中的表达及临床病理学意义。方法应用免疫组织化学方法检测Yapl在35例前列腺癌组织和16例良性前列腺增生组织中的表达，用平均吸光度值（积分吸光度／面积，IA／area）代表阳性细胞的表达水平；并探讨Yapl与前列腺癌临床病理参数之间的关系。结果Yapl在良性前列腺增生组的表达水平（IA／area=0．1867±0．0753）明显高于前列腺癌组（IA／area=0．0782-4-0．0614），两组差异有统计学意义（P〈0．01，F=16．942）；Yapl蛋白主要表达在细胞质。Yapl蛋白表达程度与前列腺癌的Gleason评分无明显相关（P〉0．05），但Yapl在Gleason7分组（IA／area=0．0548±0．0441）的表达强度高于Gleason9分组（IA／area=0．1296-4-0．0957）（P〈0．05）。结论前列腺癌中Yapl蛋白低表达可能与前列腺的发生、发展有关。Objective To study the expression of the yes-associated protein 1 （ Yapl ） in prostate cancer and its clinicopathological significance. Methods We detected the expression of the Yap1 protein in 35 prostate cancer and 16 benign prostate hyperplasia specimens by immunohistochemistry,with mean IA （IA/area） value representing expression level of positive cells. The correlation between the expression level of Yapl and the clinicopathological parameters was analyzed. Results The Yap1 protein was expressed predominantly in the cytoplasm of cells. Yap1 expression was significantly lower in prostate cancer group （IA/area =0. 0782±0. 0614） than in benign prostatic hyperplasia group （IA/area = O. 1867 ±0. 0753）, （P 〈0. 01 ,F = 16. 942）. The expression of Yapl in prostate cancer was not correlated with the Gleason score of prostate cancer （ P 〉 0. 05 ）, however, the expression of Yap1 in low pathological grading （ Gleason 7 ,IA/area =0. 0548 ＋0. 0441 ） was higher than that in high pathological grading （Gieason 9,lA/area = 0. 1296 ±0. 0957 ） ,P 〈 0. 05. Conclusion Yapl expression might be involved in prostate cancer development.

关 键 词：Yap1 前列腺癌 免疫组织化学 

分 类 号：R737.25[医药卫生—肿瘤]