Cardinal roles of miRNA in cardiac development and disease  

作　　者：FENG YuLiang YU XiYong 

机构地区：[1]Medical Research Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China [2]Southern Medical University Pharmaceutical School, Guangzhou 510515, China

出　　处：《Science China(Life Sciences)》2011年第12期1113-1120,共8页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant No. 81070103);National Natural Science Foundation of Major International Cooperation Projects in China (Grant No. 81120108003) to Yu XiYong

摘　　要：MicroRNAs(miRNAs) are small noncoding RNAs that are emerging as pivotal modulators in virtually all aspects of cardiac biology,from cardiac development to cardiomyocyte survival and hypertrophy.The miRNA profiling,following gain-and loss-of-function studies using in vitro and in vivo models,has identified wide-ranging functions for miRNAs in the heart,providing new perspectives on their contributions to cardiac pathogenesis,and revealing potential therapeutic targets and diagnostic biomarkers.This review summarizes current progress in regulation of miRNAs in heart development and disease.MicroRNAs （miRNAs） are small noncoding RNAs that are emerging as pivotal modulators in virtually all aspects of cardiac biology, from cardiac development to cardiomyocyte survival and hypertrophy. The miRNA profiling, following gain- and loss-of-function studies using in vitro and in vivo models, has identified wide-ranging functions for miRNAs in the heart, providing new perspectives on their contributions to cardiac pathogenesis, and revealing potential therapeutic targets and di- agnostic biomarkers. This review summarizes current progress in regulation of miRNAs in heart development and disease.

关 键 词：MIRNA CARDIAC DEVELOPMENT DISEASE 

分 类 号：Q522[生物学—生物化学] Q344.5