阿尔茨海默病相关的神经丝蛋白的早期诊断价值  

A study of AD7C-NTP levels in urine of patients with Alzheimer disease

作　　者：尹黎英[1] 袁慧欣[1] 张冀平[1] 师锐赞[2] 李慧媛[1] 胡为民[2] 李国平[1] 

机构地区：[1]武警山西总队医院神经内科,太原030006 [2]山西医科大学,太原030001

出　　处：《武警医学》2012年第1期28-29,34,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的探讨一种简便、可靠、无损伤、特异性较强的早期诊断阿尔茨海默病(alzheimer disease,AD)的方法。方法采用酶联免疫吸附法(ELISA)测定尿液中神经丝蛋白(alzheimer associated neuronal thread protein,AD7c-NTP)的含量,并比较38例AD患者与35例年龄相匹配的健康对照组尿中的AD7c-NTP的含量;同时分析尿中AD7c-NTP含量与智能精神状态检查量表(MMSE)、临床痴呆评定量表(CDR)和日常生活能力量表(ADL)评分的相关性。结果 AD组与对照组尿液中AD7c-NTP含量分别为(90.78±16.54)ng/ml(、70.63±12.56)ng/ml,AD组明显高于健康对照组,差异有统计学意义(P<0.05);AD组尿液AD7c-NTP含量与MMSE、CDR、ADL分数变化有一定相关性,相关系数分别为0.756、-0.658、-0.760。结论测定尿液中AD7c-NTP含量在AD早期诊断和病情评估中有重要的临床参考价值。Objective To study the value of urine AD7c-NTP levels for the early diagnosis of Alzheimer disease(AD).Methods Using enzyme linked immunosorbent assay(ELISA),the urine AD7c-NTP level was determined and compared:(1)Thirty-eight patients with dementia & 35 age-matched healthy persons;(2) the levels of urine AD7c-NTP & the scores of MMSE,CDR,ADL.Results The urine AD7c-NTP of AD group and the normal group were(90.78±16.54)ng/ml,(70.63±12.56)ng/ml,respectively.Compared with the normal mental group,the levels of urine AD7c-NTP in AD group were significantly increased(P<0.05),which was negatively correlated with the scores of MMSE(the examination of mental state),CDR(clinical dementia rating scale) and ADL(activities of daily living scale).The correlations between AD7c-NTP and MMSE(r=0.756),AD7c-NTP and CDR(r=-0.658),and AD7c-NTP and ADL(r=-0.760)were significant in AD patients(all P<0.01).Conclusions Urine AD7c-NTP levels may be an important biochemical marker for the early diagnosis and condition assessment of AD.

关 键 词：阿尔茨海默病 神经丝蛋白 智能精神状态检查量表 临床痴呆评定量表 日常生活能力量表 

分 类 号：R749.16[医药卫生—神经病学与精神病学]