A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-L-proline with aldehydes  

作　　者：ZOU ZhiQin DENG ZeJun YU XinHong ZHANG ManMan ZHAO SiHan LUO Ting YIN Xin XU HUi WANG Wei 

机构地区：[1]School of Pharmacy,Easy China University of Science&Technology,Shanghai 200237,China [2]Department of Chemistry&Chemical Biology,University of New Mexico,MSC032060,NM 87131,USA

出　　处：《Science China Chemistry》2012年第1期43-49,共7页中国科学（化学英文版）

基　　金：support from the National Natural Science Foundation of China(20972051);the Science and Technology Commission of Shanghai Municipality(08430703900 & 08431901800);the 111 Project(B07023);East China University of Science & Technology

摘　　要：An unprecedented acetic acid-catalyzed efficient access to N-alkylpyrroles from reaction of 4-hydroxy-L-proline with a variety of aldehydes has been achieved in good to excellent yields under mild reaction conditions.An unprecedented acetic acid-catalyzed efficient access to N-alkylpyrroles from reaction of 4-hydroxy-L-proline with a variety of aldehydes has been achieved in good to excellent yields under mild reaction conditions.

关 键 词：AROMATIZATION DECARBOXYLATION ENAMINES IMINIUM redox isomerization 

分 类 号：O621.254[理学—有机化学] TQ464.7[理学—化学]