介入化疗联合放疗治疗中晚期食道癌临床观察  

Clinical efficacy of combined intervention chemotherapy and radiotherapy on treating advanced esophageal carcinoma

作　　者：郭刚[1] 陈秋芬[1] 赵光锋[1] 

机构地区：[1]山东省济南市第三人民医院放射科,山东济南250101

出　　处：《海南医学院学报》2012年第2期196-198,共3页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(11221013)~~

摘　　要：目的:探讨动脉灌注化疗联合放射治疗中晚期食管癌的临床应用价值。方法:入选2006年6月～2010年7月在我院肿瘤科住院治疗的中晚期食道癌患者138例,根据治疗方法的不同分为观察组(动脉灌注化疗联合放射观察组)与对照组(单纯放射观察组)。结果:治疗后,观察组完全缓解率和总有效率分别为58.1%、91.9%,显著高于对照组35.5%和73.7%,差异具有统计学意义(P<0.05)。两组患者治疗期间并发症差异无统计学意义(P>0.05)。治疗后随访3年,观察组随访1年、2年、3年的生存率分别为69.4%、58.1%、46.8%,显著高于对照组44.7%、34.2%、22.4%,差异均有统计学意义(P均<0.01)。结论:单纯的放疗能改善患者的症状,但是在其基础上联合介入化疗,更显著改善患者的症状,提高患的预后。Objective： To investigate clinical efficacy of combined intervention chemotherapy and radiotherapy in treating advanced esophageal carcinoma.Methods：A total of 138 patients with advanced esophageal carcinoma admitted from June 2006 to July 2010were enrolled.They were divided into two groups according to different treatment： control group（radiotherapy,n=76） and treatment group（Intervention chemotherapy and radiotherapy,n=62）.The efficacy was observed and compared.Results：After treatment,the complete remission and total effective rate were 58.1%,91.9% in treatment group,significantly higher than in control group（35.5%,73.7%）（P0.05）.There was no significant difference in incidence of complications between two groups（P0.05）.Follow-up for 3 years showed that survival rate was 69.4﹪,58.1%,46.8% after one year,two year and three year,respectively.The rate was significantly higher than that of control group（44.7%,34.2%,22.4%）（P0.01）.Conclusions： Radiotherapy can improve symptom of esophageal carcinoma patients,but the efficacy of combination therapy of intervention chemotherapy and radiotherapy is more satisfactory,it can improve the prognosis of patients.

关 键 词：介入化疗 放疗 食道癌 临床疗效 

分 类 号：R735[医药卫生—肿瘤]