辣椒素敏感神经元与针刺镇痛效应的关系  

RELATION OF CAPSAICIN—SENSITIVE NEURoNES To THE EFFECT、OF ELECTRO—ACUPUNCTURE ANALGESIA

作　　者：陆卓珊[1] 曹蔚鸿[1] 董晓彤[1] 邓颖[1] 张霆钧[1] 

机构地区：[1]中国中医研究院针灸研究所,北京100700

出　　处：《针刺研究》1990年第3期213-215,共3页Acupuncture Research

摘　　要：针刺信息的外周传入途径是针刺镇痛原理的重要组成部分。实验证明针刺镇痛效应是由深部感受器及其传人纤维受刺激引起的,针刺可以兴奋各类神经纤维,但哪类纤维是传入针刺镇痛信息的,主要有两种看法:(1)认为Ⅱ类纤维与针刺镇痛有关;(2)认为Ⅳ类纤维(C-纤维)In this experiment, the rats treated with capsaicin (50mg/kg) s. c. on day 2 of liqc were used 12 weeks after injcction. The levels of substancc P(SP) in sciatic nerves and dorsal spinal cords were measured with radioimmunoassay to evaluate the extent of C-affercnt fibers damaged by capsaicin. The results as follows: (1) the levels of SP in the sciatlc nerve and the dorsal spinal cord are decreased by 69％ and by 62％ respectively, indicating the degeneration of the primary C-afferent fibers is very massive; (2) the average of basal tailflick latency (immersing in 50°C water) is prolonged 105% as compared with the control; (3) after electro-acupuncture, the average of tail-flick latency of the capsaicin treated rats is increased by 81%, while that of the vehicle treated rats increased by 54％. These data suggest that C-afferent fibers substantially mediate the transmission of noxious thermal stimuli, but is unncccssary for the transmission of acupuncture messagc to induce analgesia.

关 键 词：针灸 止痛 辣椒素 敏感神经元 

分 类 号：R346.2[医药卫生—基础医学]