趋化因子受体CXCR4和CCR7在甲状腺癌中的表达及其临床病理意义  

Expressions of Chemokine Receptor CXCR4 and CCR7 in Thyroid Cancer and Its Clinicopathologic Significance

作　　者：熊斌[1] 王崇树[2] 

机构地区：[1]川北医学院附属医院普外三科,四川南充637000 [2]川北医学院附属医院普外一科,四川南充637000

出　　处：《中国普外基础与临床杂志》2011年第12期1301-1304,共4页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探讨趋化因子受体CXCR4和CCR7在甲状腺癌中的表达及其临床病理意义。方法选取2006～2009年期间在我院行手术治疗的甲状腺癌患者55例和2009年在我院行手术治疗的甲状腺腺瘤患者30例,采用免疫组织化学染色SP法检测甲状腺癌及甲状腺腺瘤组织中的CXCR4和CCR7的表达。结果 CXCR4和CCR7在甲状腺癌中的表达阳性率均明显高于甲状腺腺瘤(P<0.01)。CXCR4和CCR7在临床分期为Ⅲ+Ⅳ期的甲状腺癌患者中的表达阳性率均明显高于临床分期为Ⅰ+Ⅱ期者(P<0.05);CCR7在有淋巴结转移的甲状腺癌中的表达阳性率明显高于无淋巴结转移者(P<0.05),而CXCR4的表达阳性率与甲状腺癌患者有无淋巴结转移无关(P>0.05);CXCR4和CCR7在甲状腺癌组织中的表达阳性率与甲状腺癌患者的年龄和性别均无关(P>0.05)。在甲状腺癌中,CXCR4阳性表达和CCR7阳性表达呈正相关(rs=0.491,P=0.000)。结论 CXCR4和CCR7协同参与了甲状腺癌的进展,可作为判断甲状腺癌预后的指标;CCR7高表达提示甲状腺癌容易发生淋巴结转移。Objective To investigate the expressions of chemokine receptor CXCR4 and CCR7 in thyroid cancer and its clinicopathologic significance. Methods Fifty-five patients with thyroid cancer were selected in the Affiliated Hospital of North Sichuan Medical College from 2006 to 2009,and 30 patients with thyroid adenoma were selected in the same hospital during 2009.The expressions of CXCR4 and CCR7 were detected in all the selected cases samples（including thyroid cancer and thyroid adenoma） by immunohistochemical SP technique. Results The positive expression rates of CXCR4 and CCR7 in the thyroid cancer were higher than those in the thyroid adenoma（P〈0.01）,which in the thyroid cancer with clinical stage Ⅲ＋Ⅳ were higher than those of the clinical stage Ⅰ＋Ⅱ（P〈0.05）.The positive expression rate of CCR7 in the thyroid cancer with lymph node metastasis was higher than that of the thyroid cancer without lymph node metastasis（P〈0.05）,which of CXCR4 in the patients with thyroid cancer was independent of lymph node metastasis（P〉0.05）,and which of CXCR4 and CCR7 were also independent of the age and gender of the patients with thyroid cancer（P〉0.05）.The positive expressions of CCR7 and CXCR4 in all the patients with thyroid cancer was positively correlated（rs=0.491,P=0.000）. Conclusions CXCR4 and CCR7 are involved in the coordination of thyroid cancer progression.They can be used as prognostic indicators of thyroid cancer.High expression of CCR7 is prone to lymph node metastasis of thyroid cancer.

关 键 词：甲状腺癌 CXCR4 CCR7 

分 类 号：R736.1[医药卫生—肿瘤]