沙生蜡菊花降脂活性部位化学成分的分离与鉴定(Ⅱ)  

Isolation and identification of chemical constituents in the lipid-lowering fraction of Flos Helichrysum arenarium(Ⅱ)

作　　者：王立波[1] 刘凤芝[1] 甘春丽[1] 董乃维[1] 侯云龙[1] 王策[1] 

机构地区：[1]哈尔滨医科大学药学院,黑龙江哈尔滨150081

出　　处：《沈阳药科大学学报》2012年第2期109-112,125,共5页Journal of Shenyang Pharmaceutical University

基　　金：黑龙江省教育厅科学技术研究资助项目(11551279)

摘　　要：目的沙生蜡菊花降脂活性部位中的化学成分研究。方法采用硅胶、ODS、制备HPLC等多种色谱方法分离纯化,依据理化性质、波谱数据分析进行结构鉴定。结果从沙生蜡菊花的降脂活性部位中分离得到11个化合物,并分别鉴定为:丁香苷(syringin,1)、二氢丁香苷(dihydrosyringin,2)、(E)-4-hydroxybenzalacetone-3-O-β-D-glucopyranoside(3)、4-烯丙基-2-甲氧基苯基1-O-β-D-呋喃芹糖(1-6)-β-D-吡喃葡萄糖苷[4-allyl-2-methoxyphenyl 1-O-β-D-apiofuranosyl-(1-6)-O-β-D-glu-copyranoside,4]、苔黑酚-β-D-吡喃葡萄糖苷(orcinol-β-D-glucopyranoside,5)、7-hydroxy-5-me-thoxyphthalide-7-O-β-D-glucopyranoside(6)、5,7-dihydroxyphthalide-7-O-β-D-glucopyranoside(7)、undulatoside A(8)、adenosine(9)、maltol-3-O-β-D-apiofuranosyl-(1-6)-β-D-glucopyranoside(10)、2,4,6-三羟基苯乙酮-2,4-二-O-β-D-吡喃葡萄糖苷(2,4,6-trihydroxylacetophenone-2,4-di-O-β-D-glu-copyranoside,11)。结论化合物1～11均为首次从蜡菊属植物中分离得到。Objective To study the chemical constituents in the lipid-lowering fraction of Flos Helichrysum arenarium. Methods The chemical constituents were isolated by various methods of isolation （ silica gel, ODS and HPLC column chromatography）and their structures were elucidated by the analysis of spectral data and chemical properties. Results Eleven compounds were identified as syringin（ 1 ）, dihydrosyringin（2 ）, （E）-4- hydroxybenzalacetone-3-O-β-D-glucopyranoside （ 3 ）, 4-allyl-2-methoxyphenyl-l-O-β-D-apiofuranosyl-（ 1- 6） -O-β-D-glucopyranoside （ 4 ）, orcinol-β-D-glucopyranoside （ 5 ）, 7-hydroxy-5-methoxyphthalide-7-O-fl-D- glucopyranoside （ 6 ）, 5,7-dihydroxyphthalide-7-O-β-D-glucopyranoside （ 7 ）, undulatoside A （ 8 ）, adenosine （ 9 ）, maltol-3 -O-β-D-apiofuranosyl- （ 1-6 ） -β-D-glucopyranoside （ 10 ）, and 2,4,6-trihydroxylacetoplaenone- 2,4-di-O-fl-D＇-glucopyranoside（11）. Conclusions Compounds 1-11 are obtained from Helichrysum for the first time.

关 键 词：沙生蜡菊花 降脂活性部位 化学成分 结构鉴定 

分 类 号：R914[医药卫生—药物化学] R284.1[医药卫生—药学]