艾迪注射液联合GP化疗治疗老年晚期非小细胞肺癌的临床疗效评价  

Evaluation on clinical efficacy of Aidi injection combined with GP chemotherapy in treatment of advanced non-small cell lung cancer in elder patients

作　　者：孙金波[1] 徐沛然[1] 石东磊[1] 曹彬[1] 

机构地区：[1]吉林大学第二医院胸外科,吉林长春130041

出　　处：《吉林大学学报（医学版）》2012年第1期151-154,共4页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅社会发展基金资助课题(92226000)

摘　　要：目的:观察单纯GP方案和艾迪注射液联合GP(吉西他滨+顺铂)化疗方案治疗老年晚期非小细胞肺癌(NSCLC)的效果,阐明艾迪注射液对老年晚期NSCLC化疗的效果。方法:将68例60岁以上晚期NSCLC患者按住院号奇偶数随机分为联合治疗组和单纯GP组(每组各34例)。治疗组给予艾迪注射液+GP方案,对照组给予单纯GP方案,至少2个化疗周期后评价临床疗效。结果:2组近期疗效比较差异无统计学意义(P>0.05);2组患者生活质量Karnofsky评分提高比较,治疗组明显高于对照组(P<0.05);治疗组白细胞减少明显低于对照组(P<0.05);治疗组消化道反应(恶心、呕吐)及肝、肾功能损害发生率低于对照组,但差异无统计学意义(P>0.05)。结论:艾迪注射液联合GP化疗治疗NSCLC较单纯GP化疗在改善生活质量及减少化疗毒副作用方面效果更好。Objective To observe the efficacies of GP chemotherapy and GP chemotherapy combined with Aidi injection in treatment of advanced non-small cell lung cancer（NSCLC） in elder patients and clarify the essentiality of Aidi injection for treating elder patients with advanced NSCLC.Methods 68 patients beyond 60 years old with advanced NSCLC were randomly divided into combined treatment group and GP group.The patients in treatment group received both GP chemotherapy and Aidi injection,the patients in GP group received GP chemotherapy only.The efficacy was analyzed after at least two cycles.Results The short-term effect had no significant difference between two groups（P0.05）.The elevated rate of Karnofsky score in two groups was significantly different（P0.05）.The incidence rate of leucopenia in combined treatment group was significantly lower than that in GP group（P0.05）.The incidence rate of gastrointestinal tract and the damage of liver and renal in combined treatment group were lower than those in GP group,but there were no significant differences（P0.05）.Conclusion Aidi injection combined with GP chemotherapy has significant effect on improving quality of life and reducing the side effects of chemotherapy in elder patients with advanced NSCLC.

关 键 词：癌 非小细胞肺 药物疗法 艾迪注射液 吉西他滨 顺铂 

分 类 号：R734.2[医药卫生—肿瘤]