芩连液与白虎汤对气分证家兔免疫调节及抗氧化活性的影响比较  

Effect of Baihu Soup and Qinlian Liquid on Immunoregulation and Anti-Oxidation Activity in Rabbit with Qifen Syndrome

作　　者：张世栋[1] 严作廷[1] 王东升[1] 李世宏[1] 荔霞[1] 李锦宇[1] 李宏胜[1] 陈炅然[1] 龚成珍[2] 

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所,中国农业科学院临床兽医学研究中心,农业部兽用药物创制重点实验室,甘肃兰州730050 [2]甘肃农业大学动物医学院,甘肃兰州730070

出　　处：《中国畜牧兽医》2012年第1期181-184,共4页China Animal Husbandry & Veterinary Medicine

基　　金：“十一五”国家科技支撑计划重点课题(2008BADB4B01-2)

摘　　要：为比较自拟方芩连液和白虎汤对气分证的疗效差别,以静脉注射脂多糖(LPS)制作气分证家兔模型,在两种药物治疗前后分别检测了血清免疫球蛋白IgG、IgM和IgA的含量变化,以及血清超氧化物歧化酶(SOD)、丙二醛(MDA)和总抗氧化能力(T-AOC)的变化。结果显示,白虎汤对气分证家兔升高了的血清免疫球蛋白和T-AOC的含量变化无显著影响,但能使血清SOD下降,MDA上升;芩连液可使得IgM和IgG含量下降,SOD上升,MDA无显著变化,而T-AOC含量下降。结果表明,白虎汤对气分证家兔免疫调节和总抗氧化能力的保持优于芩连液,但对SOD和MDA调节不及芩连液。To compare the treatment efficacy of Qinlian liquid with Baihu soup,the model of Qifen syndrome was founded through LPS injection intravenously in rabbit.Animal serum was collected before and after treatment with two formulas respectively,and IgG,IgM,IgA,SOD,MDA and T-AOC were detected successively.The results showed that there is no striking impact from Baihu soup to serum immunoglobulin and T-AOC in model animals,but SOD was decreased and MDA （increased.）Then,Qinlian liquid made IgG and IgM decrease,SOD increase,but T-AOC decrease,and MDA hold the line.These results indicated Baihu soup had more advantages than Qinlian liquid on immunoregulation and total antioxidant capacity,but Baihu soup was not as good as Qinlian liquid on SOD and MDA regulation.

关 键 词：气分证 免疫调节 抗氧化活性 脂多糖 中药 

分 类 号：S853.7[农业科学—临床兽医学]