脑梗死与血脂和血尿酸水平的关系探讨  

Relationship Between Lipids and uric acid levels in Patients with Transient

作　　者：肖利杰[1] 魏秀娥[1] 

机构地区：[1]江苏徐州医学院第二附属医院,江苏省徐州市221006

出　　处：《临床合理用药杂志》2011年第12X期28-29,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨脑梗死与血脂、血尿酸水平的关系。方法选择我院住院诊断为脑梗死患者240例,经颅多普勒超声检查及颈动脉超声检查,其中38例提示有颅内或颅外动脉狭窄(狭窄组),其余52例为非狭窄患者(非狭窄组),另选择40名年龄和性别与狭窄组、非狭窄组相匹配的体格检查健康者为对照组。采用全自动生化分析仪测定3组患者血脂、血尿酸水平。结果血管狭窄组患者血浆总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白(LDL-c)及血尿酸(UA)分别为(4.7±0.7)mmol/L、(1.7±0.8)mmol/L、(3.7±0.8)mmol/L和(420.1±98.2)μmol/L;非狭窄组患者为(4.2±1.0)mmol/L、(1.6±0.5)mmol/L、(3.4±0.6)mmol/L和(398.6±78.1)μmol/L;对照组为(3.5±0.9)mmol/L、(1.4±0.7)mmol/L、(2.8±0.9)mmol/L和(310.5±60.6)μmol/L。狭窄组、非狭窄组与对照组比较,差异均有统计学意义(P<0.01);狭窄组与非狭窄组血浆TC、TG、LDL-c、UA水平比较,差异亦有统计学意义(P<0.01);UA与TC、TG、LDL-c比较,差异无统计学意义(P>0.05)。结论血浆TC、TG、LDL-C、UA水平增高,是短暂性脑缺血发作患者独立危险因素,且与血管狭窄相关。Objective To explore the relationship between plasma lipid and uric acid levels in Patients with Transient Ischemic Attack.Methods A total of 90 patients with TIA were selected.Transcranial Doppler（TCD） and carotid doppler ultrasound sonography found that 38 patients had intracranial arterial stenosis（stenotic group） and 52 patientswithout stenosis（nonstenotic group） .In addition,40 age and sex matched healthy controlswere selected as control group.Plasma lipid and uric acid levelswere detected by automatic biochemistry analyzer in the 3 groups.Results The levels of plasma total cholesterol（TC） ,triglyceride（TG） ,low density lipop rotein cholesterol（LDL-c） ,and uric acid in the stenotic group were（4.7±0.7） 、（1.7±0.8） 、（3.7±0.8） mmol/L和（420.1±98.2） μmol/L,respectively;they were（4.2±1.0） 、（1.6±0.5） 、（3.4±0.6） mmol/L和（398.6±78.1） μmol/L,respectively in the nonstenstic group;and theywere（3.5±0.9） 、（1.4±0.7） 、（2.8±0.9） mmol/L和（310.5±60.6） μmol/L,respectively in the control group.There were significant differences between the stenotic and nonstenotic group s with the control group（P0.01） ;and there were significant differences between the stenotic group and the nonstenotic group either in the levels of plasma TC,TG,LDL-c,and uric acid（P 0.01） .Uric acid and plasma TC,TG,LDL-c have no significant correlation（P0.05） .Conclusion The increase of the levels of plasma TG,LDL-c and uric acid are the independent risk factors of TIA patients.There was positive correlation with intracranial arterial stenosis.

关 键 词：短暂性脑缺血发作 血管狭窄 血脂 血尿酸 

分 类 号：R743.33[医药卫生—神经病学与精神病学]