血清层粘蛋白、透明质酸、胶原Ⅳ测定对早期肝硬化诊断的实验研究  

Experiniental Study on Early Liver Cirrhosis by Measuring Serum, Laminin Hyaluronic Acid and Cullagen Ⅳ

作　　者：孙远杰[1] 董秀英[1] 邵焱 杨丽 尹晓光[1] 张维平[1] 于世海 张季[1] 谢丽华 刘海洋 

机构地区：[1]中国第一汽车集团公司职工医院,长春市130011

出　　处：《中国厂矿医学》2000年第1期1-2,共2页Chinese Medicine of Factory and Mine

基　　金：长春市科学技术委员会资助

摘　　要：目的寻找一种无创性的、简便而有效的早期肝硬化诊断方法。方法采用四氯化碳建立大鼠肝硬化模型，观察血清层粘蛋白、胶原Ⅳ和透明质酸的含量变化与肝硬化程度的关系。结果肝硬化早期层粘蛋白、透明质酸以及胶原Ⅳ即开始升高，并与肝脏组织变化和肝功能变化呈平行关系。结论层粘蛋白、透明质酸、胶原Ⅳ是反映早期肝硬化的较好的指标。CCl_4 was used to establish a model of mice's liver Cirrhosis. We observed the change of serum luminin (LN), hyaluronicacid and collagen Ⅳ(CⅣ ),and studied the relation between their content and degree of liver cirrhosis. The results showed that the content of serum in, CⅣ and LN began rising in the early liver cirrhosis, and they paralleled the degree of pathological change and liver function. This study showed that serum HA, CⅣ and LN may be used new markers for the early liver fibrosis or cirrhoses.

关 键 词：肝硬化 层粘蛋白 透明质酸 胶原Ⅳ 诊断 

分 类 号：R575.204[医药卫生—消化系统]