^99Tcm-硫胶体及其联合染色法对早期乳腺癌前哨淋巴结探测的比较  

Comparison of radioactive sulfur colloid and combined methylene blue injection methods for detection of sentinel lymph node in early breast cancer

作　　者：俞丹[1] 许林[2] 洪明[2] 吴华[1] 苏新辉[1] 陈贵兵[1] 

机构地区：[1]厦门大学附属第一医院核医学科,361003 [2]厦门大学附属第一医院肿瘤科,361003

出　　处：《国际放射医学核医学杂志》2011年第5期281-284,共4页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：目的评价单用^99Tcm-硫胶体和^99Tcm-硫胶体与亚甲蓝联合应用探测早期乳腺癌前哨淋巴结（SLN）的效能。方法76例早期乳腺癌患者分为单用卵^99Tcm-硫胶体组（25例）和^99Tcm-硫胶体与亚甲蓝联合组（51例），分别在术前进行乳腺癌SLN探测，以腋窝淋巴结病理检查结果作为评价标准。结果76例患者中成功探测到SLN74例，SLN的检出率、准确率、灵敏度和假阴性率在^99Tcm-硫胶体组分别为92．0％、95．7％、90．0％、10．0％；在联合组分别为100％、98．0％、95．2％、4．8％。结论乳腺癌SLN探测可较准确预测腋窝淋巴结的转移状况，为外科医生确定手术方式提供重要信息，联合应用^99Tcm-硫胶体和亚甲蓝可提高SLN的检出率和准确率，降低假阴性率。Objective To compare the efficacy of ^99Tcm-sulfur colloid and combined ^99Tcm-sulfur colloid/methylene blue methods for detection of sentinel lymph node （SLN） in early breast cancer. Methods Seventy-six patients with early breast cancer were dived into two groups. In group 1 （n=25）, ^99Tcm-sulfur colloid detection was used alone. In group 2 （n=51）, both ^99Tcm-sulfur colloid detection and methylene blue methods were used. The pathological findings of resected axillary lymph nodes were regarded as evaluation standard. Results In 76 patients SLN was successfully detected in 74 cases. The SLN detection rate, accuracy, sensitivity and the false negative rate for ^99Tcm-sulfur colloid group and combined group were 92.0% vs. 100%, 95.7% vs. 98.0%, 90.0% vs. 95.2%, and 10.0% vs. 4.8% respectively. Conclusions SLN detection in early breast cancer may accurately predict axillary lymph node metastasis, thus providing important infor- mation for surgery. Combined use of ^99Tcm-sulfur colloid and methylene blue methods may improve the SLN detection accuracy and reduce false negative rate.

关 键 词：乳腺肿瘤 前哨淋巴结活组织检查 硫胶体 亚甲蓝 

分 类 号：R737.9[医药卫生—肿瘤]