阻塞性睡眠呼吸暂停作为缺血性卒中独立危险因素的可能机制  

Obstructive sleep apnea as an independent risk factor for stroke： possible mechanislms

作　　者：张圣[1] 殷梅[1] 

机构地区：[1]昆明医学院第二附属医院神经内科,650101

出　　处：《国际脑血管病杂志》2011年第12期911-915,共5页International Journal of Cerebrovascular Diseases

摘　　要：阻塞性睡眠呼吸暂停（obstructive sleep apnea,OSA）是最常见的睡眠呼吸障碍类型,与缺血性卒中的发病紧密相关.业已证实,OSA是缺血性卒中的一个独立危险因素,其致病机制包括因长期间断性低氧血症和高碳酸血症引起的动脉粥样硬化形成、凝血功能异常以及脑血流动力学改变.合并OSA的缺血性卒中患者预后较差,因此需及早开始治疗以避免脑组织进一步损伤并降低病死率.Obstructive sleep apnea （OSA）,the most common type of sleep disordered breathing was closely associated with the occurrence of ischemic stroke.It has been demonstrated that OSA is an independent risk factor for ischemic stroke.Its pathogenic mechanism includes atherosclerosis,coagulation abnormalities and cerebral hemodynamic changes caused by long-term periodic hypoxia hypoxemia and hypercapnia.The prognosis of ischemic stroke patients with OSA is poor.Therefore,it needs to be treated early to avoid further damage to brain tissue and reduce the mortality.

关 键 词：睡眠呼吸暂停综合征 卒中 脑缺血 动脉粥样硬化 氧化性应激 炎症 止血 脑血管 循环 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]