血清CEA和CYFRA21-1对非小细胞肺癌诊断价值的系统评价  

A systematic review of diagnosis value for CEA and CYFRA21-1 in non-small-cell lung cancer

作　　者：谢树钦[1] 杨惠洁[1] 鲍依稀[1] 

机构地区：[1]重庆医科大学附属第二医院检验科,400010

出　　处：《国际检验医学杂志》2011年第21期2429-2432,共4页International Journal of Laboratory Medicine

基　　金：重庆市自然科学基金资助项目(CSTC;2009BB5399)

摘　　要：目的探讨血清CEA和CYFRA21-1对非小细胞肺癌(NSCLC)的诊断价值。方法计算机检索PubMed、CBM等数据库中的文献,按照纳入排除标准筛选文献,提取纳入研究的特征信息。统计分析过程采用Meta-DiSc 1.4软件。采用QUA-DAS量表进行严格的质量评价,根据异质性特点选择相应效应模型进行计算合并的敏感度、特异度,绘制SROC曲线,并计算曲线下面积(AUC)。结果共检索到相关文献1 679篇,最终纳入38篇文献。经过病理金标准确诊NSCLC患者5 140例,对照组3 834例。Meta分析结果显示,CEA、CYFRA21-1及CEA+CYFRA21-1组的各纳入研究间均存在异质性,SROC曲线下面积分别为0.723 0、0.880 4、0.913 4。结论 CEA、CYFRA21-1对NSCLC皆有一定的诊断价值,联合CEA和CYFRA21-1可进一步提高对NSCLS的诊断效能。Objective To evaluate the diagnostic value of serum CEA and CYFRA21-1 in patients with suspected NSCLC with lung pathological diagnosis as the gold standard.Methods PubMed,CBM etc.were searched for studies about serum CEA and CYFRA21-1 in the diagnosis of NSCLC.We screened studies identified for inclusion and determined study eligibility according to the criteria of inclusion and exclusion.The characteristics of the included articles were appraised and extracted.Statistical analysis was performed by Meta-DiSc 1.4 software.Quality of included trials was assessed by QUADAS.Then the summary receiver operating characteristic curve（SROC） was performed and the area under the curve（AUC） was calculated.Results 38 articles were included in this meta-analysis while 1 679 articles were searched.The studies involved 5 140 NSCLC patients and 3 834 cases as the control group.The meta-analysis reported that the heterogeneity among studies（CEA,CYFRA21-1,CEA＋CYFRA21-1） was high.The AUC were 0.723 0,0.880 4 and 0.913 4,respectively.Conclusion The diagnosis value of CEA and CYFRA21-1 in NSCLC is confirmed,while combining CEA and CYFRA21-1 can further improve the diagnosis.

关 键 词：癌 非小细胞肺 诊断 CEA CYFRA21-1 系统评价 

分 类 号：R734.2[医药卫生—肿瘤]