射频消融联合经动脉化疗栓塞治疗肝癌的疗效分析  

Transarterial Chemoembolization in Combination with Radiofrequency Thermal Ablation in Hepatocellular Carcinoma:a Systematic Review and Meta-analysis

作　　者：孙贤俊[1] 何胜利[1] 沈婕[1] 陈颢[2] 陈越[3] 蒋霆辉[3] 

机构地区：[1]复旦大学附属肿瘤医院闵行分院肝胆胰中西医结合科,上海200240 [2]复旦大学附属肿瘤医院中西医结合科,上海200032 [3]上海中医药大学附属岳阳医院肿瘤介入科,上海200437

出　　处：《中国临床医学》2011年第6期803-808,共6页Chinese Journal of Clinical Medicine

基　　金：上海市闵行区科委课题(编号:2009MHZ022)

摘　　要：目的:比较经动脉灌注化疗栓塞(transcatheter arterial chemoembolization,TACE)联合射频消融(radiofrequency ablation,RFA)治疗肝细胞肝癌(hepatocellular carcinoma,HCC)与单独TACE或RFA治疗的临床远期疗效。方法:通过计算机和手工检索收集国内外关于TACE+RFA与单独TACE或RFA治疗无法手术切除肝癌的临床随机对照研究文献,并按Cochrane协作网推荐的方法进行Meta分析。采用RevMan 4.2软件,对符合纳入标准的8个研究进行Meta分析。结果:联合治疗组的1、2、3年生存率显著优于单独治疗组(均P<0.05)。亚组分析结果显示:1年生存率联合治疗组和RFA组无显著差异;联合治疗组1、2、3年生存率显著优于TACE组(均P<0.01)。结论:TACE联合RFA治疗无法手术切除肝癌的远期疗效较单独治疗好,能有效提高患者生存率。Objective：To compare the therapeutic effects of transcatheter arterial chemoembolization（TACE） plus radiofrequency ablation（RFA） to TACE or RFA alone for hepatocellular carcinoma（HCC）.Methods：All data of patients with HCC underwent TACE ＋ RFA versus TACE or RFA were collected from literature by electronic searching and handwork searching. Meta-analysis that recommended by Cochrane Collaboration was done for the data above,8 researches enrolled in criteria were included in this study using RevMan 4.2.Results：Compared with that of TACE or RFA alone,1-,2-,3- year survival in those underwent TACE ＋ RFA was statistically higher（P〈0.05）,Subgroup analysis showed：TACE ＋ RFA group in lyear survival rate was no significant difference in RFA group,Compared with that of TACE alone,1-,2-,3-year survival in those underwent TACE ＋ RFA was statistically higher（P〈0.001）.Conclusions：The prospective efficacy of TACE plus RFA for HCC which can elevate the patients＇ survival rate is better than that of TACE or RFA alone.

关 键 词：肝癌 射频消融 经动脉化疗栓塞术 META分析 生存率 

分 类 号：R735.7[医药卫生—肿瘤]