TC-1蛋白表达在肿瘤发生发展中的作用  

Role of thYroid cancer-I in tumorigenesis and progression

作　　者：张琪瑶[1] 徐洪涛[1] 

机构地区：[1]中国医科大学临床医学七年制,沈阳110001

出　　处：《国际肿瘤学杂志》2012年第2期83-85,共3页Journal of International Oncology

基　　金：国家自然科学基金资助项目（30801135）

摘　　要：TC-1是由TC-1基因编码的核蛋白，能够调控细胞分裂周期，参与基因转录和翻译的调节，与正常细胞和肿瘤细胞的增殖有关。TC-1参与Wnt信号转导通路的激活，可以促进多种癌基因表达上调，与甲状腺癌、胃癌、乳腺癌等肿瘤的恶性转化和进展有关。TC-1作为一种潜在的肿瘤相关蛋白，将有望用于肿瘤的基础理论研究和基因靶向治疗。thyroid cancer（TC-1 ）, a nuclear protein coded by TC-1, regulates the cell cycle, participates transcription and translation, and is correlated with the proliferation of normal and cancer cells. TC-1 participates in the Wnt/beta-catenin signaling pathway which can promote the up-regulation of proto-oncogene. Hence it plays an important role in the malignant transformation and development of the tumors, such as thyroid cancer, gastric cancer and breast cancer. Therefore, as a potential tumor-associated protein, it＇s likely to be used for fundamental research and gene targeting therapy.

关 键 词：肿瘤 基因 信号传导 TC-1 

分 类 号：R730.2[医药卫生—肿瘤]