乳腺癌扩增基因1与肿瘤  

Amplified in breast cancer 1 in tumorigenesis

作　　者：吴晓[1] 洪超群[1] 吴名耀[2] 

机构地区：[1]汕头大学医学院附属肿瘤医院肿瘤病理科,515041 [2]汕头大学医学院附属肿瘤医院病理教研室,515041

出　　处：《国际肿瘤学杂志》2012年第2期99-101,共3页Journal of International Oncology

基　　金：广东省科技计划基金资助项目（20098030801317）

摘　　要：乳腺癌扩增因子（AIB）1通过与核受体结合从而在基因表达调控过程中发挥重要作用。大量研究表明，AIB1在乳腺癌、子宫内膜癌、前列腺癌、食管癌、结直肠癌等多种肿瘤中均呈过表达。对AIB1在多种肿瘤的发病机制以及预后中作用的研究，将有助于重新了解肿瘤癌变的过程。AIB1可能成为新的预后指标及治疗靶点。Amplified in breast cancer 1 （AIB1） plays an important role in the process of gene expression and regulation by combining with nuclear receptor. Aberrant expression of AIB1 has been detected in different types of caners, such as breast cancer, endometrial carcinoma, prostate cancer, esophageal squamous cell carcinoma, colorectal carcinoma, etc. The study of the potential role of AIB1 in the pathogenesis and prognosis will improve our general acknowledge of carcinogenesis. AIB1 may become a new prognostic nmrker as well as a new therapeutic target.

关 键 词：肿瘤 受体 类固醇 转录因子 

分 类 号：R737.9[医药卫生—肿瘤]