Hedgehog信号通路与肿瘤的关系  

Hedgehog signaling pathway and tumors

作　　者：曹响元[1] 赵耀东[1] 楼美清[1] 

机构地区：[1]同济大学附属第十人民医院神经外科,上海200072

出　　处：《国际肿瘤学杂志》2012年第2期102-104,共3页Journal of International Oncology

基　　金：国家自然科学基金资助项目（20111909）

摘　　要：Hedgehog（Hh）信号通路在脊椎动物胚胎发育过程中起核心作用，参与调控多个基本生命过程，包括细胞增殖、分化和组织塑形。在正常成人该通路涉及干细胞维持、组织修复和再生等过程。目前越来越多的证据表明Hh信号通路与人类肿瘤的增殖、生存能力等有相关性。The Hedgehog. （Hh） signaling pathway plays a central important role during embryo development of vertebrate, which participates in regulation of multiple basic life processes including cell proliferation, differentiation and tissue patterning. In normal adult physiology, the pathway is implicated in stem cell maintenance, tissue repair and regeneration. By now, more and more researches have been indicated that the Hh signaling pathway is related to the tumor growth promoting and survival capabilities.

关 键 词：肿瘤 基底细胞 髓母细胞瘤 神经胶质瘤 肿瘤干细胞 HEDGEHOG信号通路 

分 类 号：R739.4[医药卫生—肿瘤]