磷脂酰肌醇3激酶-蛋白激酶B信号通路在结肠癌中的作用  

The effect of phosphatidylinositol-3-kinase -protein kinase B signal pathway in colon cancer

作　　者：马冬华[1] 张亮[1] 王亚旭[1] 

机构地区：[1]重庆医科大学附属第二医院胃肠外科

出　　处：《国际肿瘤学杂志》2012年第2期143-145,共3页Journal of International Oncology

摘　　要：磷脂酰肌醇3激酶-蛋白激酶B（P13K-Akt）信号通路异常激活已经被证实与多种肿瘤发生发展密切相关，并且P13K-Akt通路在结肠癌的发生发展中起重要作用，它参与调控结肠肿瘤细胞存活和增殖、抑制凋亡、促进细胞周期进程等，并且通过抑制该通路还可能在结肠癌治疗中有潜在作用。The abnormal activation of phosphatidylinositol-3-kinase （PI3K）-protein kinase B （Akt） pathway has already been confirmed to be closely related to the origin and development of various tumors. PI3K- Akt pathway plays an important role in development of colon cancer, it carl regulate cell survival, proliferation, anti-apoptosis, cell cycle progression, etc. Furthermore, inhibition of this pathway may play a potential roll in oncotherapy.

关 键 词：信号传导 药理作用分子作用机制 结肠肿瘤 磷脂酰肌醇3激酶-蛋白激酶B信号通路 

分 类 号：R735.35[医药卫生—肿瘤]