小儿急性淋巴细胞白血病p16基因缺失的研究  

INVESTIGATION OF P16 (MTS1) GENE DELETION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

作　　者：吕昌龙[1] 付国[1] 阎建忠[1] 张瑞英[1] 

机构地区：[1]中国医科大学,沈阳110001

出　　处：《肿瘤》2000年第1期60-62,共3页Tumor

摘　　要：目的　了解p16(MTS1)基因缺失在小儿急性淋巴细胞白血病(ALL)发病中的意义。方法　应用PCR和Southern 印迹杂交技术检测了47 例小儿ALL样品中p16基因的缺失。结果　全部被检样品中有9例存在p16 基因缺失,缺失率为19.1 % 。其中,8例T细胞型ALL(T-ALL)中有5 例显示缺失,缺失率为62.5 % ;39 例前B细胞型ALL(pre-B-ALL)中有4 例显示缺失,缺失率为10.3 % 。结论　p16 基因缺失与小儿ALL。Objective To investigate the possible relationship between p16 gene deletion and pathogenesis of pediatric acute lymphoblastic leukemia (ALL). Methods Polymerase chain reaction (PCR) and Southern blotting technique were used to analyse p16 gene deletion in DNA samples from 47 patients. Results p16 gene deletion was detected in 9 out of the total, including 5 out of 8 T ALL and 4 out of 39 pre B ALL patients. Conclusion The high frequency of p16 gene deletion might contribute to the development of pediatric ALL, especially T ALL.$$$$

关 键 词：白血病 ALL 基因缺失 儿童 P16基因 

分 类 号：R733.710.2[医药卫生—肿瘤]