西咪替丁对围手术期胃肠癌患者T细胞亚群的影响  

Effects of cimetidine on T lymphocyte subsets in perioperative gastrointestinal cancer patients

作　　者：白德骄[1] 杨国梁[1] 袁宏银[1] 李雁[1] 王坤[1] 

机构地区：[1]湖北医科大学附属第二医院肿瘤科,湖北省武汉市430071

出　　处：《世界华人消化杂志》2000年第2期147-149,共3页World Chinese Journal of Digestology

摘　　要：目的 研究西咪替丁对围手术期胃肠癌患者外周血T细胞亚群免疫功能的影响。 方法 胃肠癌患者49例,以围手术期是否应用Gim(400mg,3次/d,po,术前7d～10d;600mg,2次/d,至术后10d)随机分成治疗组和对照组。于入院时,手术前、手术后2,10d各抽取外周血1次,用免疫细胞化学方法检测T细胞亚群(鼠抗人CD3,CD4,CD8单抗)的变化。 结果 与正常人相比,治疗组与对照组中的胃肠癌患者外周血CD3^+,CD4^+细胞数明显减少(P<0.01),CD8^+细胞数明显增多(P<0.05),CD4^+/CD8^+比值明显降低(P<0.01)。治疗组与对照组相比,入院时两者间各指标无显著性差别(P>0.05),术前1d,术后2,10d的CD3^+,CD4^+,CD4^+/CD8^+高于对照组(P<0.01)。术后与术前相比,治疗组和对照组细胞免疫功能均下降,表现为CD3^+,CD4^+,CD4^+/CD8^+降低,CD8^+升高(P<0.05),但治疗组免疫功能下降的幅度低于对照组。 结论 胃肠癌患者细胞免疫功能下降,手术使其细胞免疫功能进一步下调;Cim能增强患者细胞免疫功能,降低手术对机体免疫损害的程度。AIM To study the effects of cimetidine (Cim) on the immune function of peripheral blood lymphocyte subsets in patients with gastrointestinal cancer. METHODS Forty-nine patients were divided into treatment group ( n = 25 ) who took Cim during perioperative period, and control group (n = 24) who did not take any medicine. CD3+ , CD4+ and CD8+ cells were measured by immunocytochemical stain method in the perioperative period.RESULTS Compared with normal control, the percentages of CD3+ , CD4+ cells and CD4+ /CD8+ ratio in patients with gastrointestinal cancer were significantly lower (P<0.01), and the percentage of CD8+ cells was significantly higher (P<0.05). At admission, the parameters were not significantly different between treatment group and control group (P>0.05), while the percentages of CD3+ , CD4+ cells and CD4+/ CD8+ ratio before operation, on the 2nd and 10th postoperative days in the treatment group were significantly higher than those in the control group (P<0.01). The cellular immunity-positive cells in both groups were much lower after operation than before operation (P<0.05). However, the degree of decrease was much smaller in the treatment group than in the control group.CONCLUSION The cellular immunity-positive cells are lower in gastrointestinal cancer patients, and they are further down-regulated by operation. Cim can boost the patients' cellular immunity, and alleviate the damage to hosts' immunity due to operation.

关 键 词：胃肠肿瘤 T淋巴细胞亚群 西咪替丁 围手术期 

分 类 号：R735[医药卫生—肿瘤]