前列腺特异性抗原普查在诊断前列腺癌中的作用  

Role of prostate specific antigen in the diagnosis of prostate carcinoma

作　　者：张晓春[1] 那彦群[1] 郭应禄[1] 

机构地区：[1]北京医科大学第一医院泌尿外科,北京医科大学泌尿外科研究所100034

出　　处：《中华泌尿外科杂志》2000年第1期37-40,共4页Chinese Journal of Urology

摘　　要：目的　了解血清总前列腺特异抗原（ＴＰＳＡ）、游离ＰＳＡ（ＦＰＳＡ）、ＰＳＡ密度（ＰＳＡＤ）在诊断前列腺癌中的作用。　方法　门诊检查４０ 岁以上男性病人ＰＳＡ共３２４ 例，活检筛查出前列腺癌９例（２－８ ％） ，将病人分组进行比较。　结果　前列腺癌组ＴＰＳＡ、ＦＰＳＡ 和ＰＳＡＤ 高于前列腺增生和其他疾病组（ Ｐ＜０－０５） 。血清ＴＰＳＡ＜ ４ｎｇ／ｍｌ、４ ～１０ｎｇ／ｍｌ、＞ １０ｎｇ／ｍｌ 者发现前列腺癌的比例分别为０－５ ％ 、４－１ ％ 、１０－９％ ，三组病人Ｆ／ＴＰＳＡ 以及Ｆ／ＴＰＳＡ≤和＞ ０－１６ 所占比例差异无显著性。　结论　直肠指诊和ＴＰＳＡ 检查是筛查前列腺癌最重要的指标，ＦＰＳＡ、Ｆ／ＴＰＳＡ和ＰＳＡＤ检查有一定的帮助。Objective To study the role of T PSA,F PSA,F/T PSA and PSAD in the diagnosis of prostate carcinoma. Methods T PSA,F PSA,F/T PSA and PSAD were studied in 324 males over 40 years of age.Biopsy was carried out when needed. Results 9 prostate carcinoma (2.8%) were found out of 324 as verified on biopsy.T PSA,F PSA and PSAD were higher in the carcinoma group ( P <0.05).The incidence of prostate carcinoma with T PSA 4ng/ml,4～10ng/ml and 10ng/ml were 0.5%,4.1% and 10.9% respectively.There was no statistic difference of F/T PSA between the 3 groups and also no statistic difference between F/T PSA under and above 0.16. Conclusions Digital rectal examination and T PSA assay are the most important means to discover prostate carcinoma and F/T PSA and PSAD might be helpful.

关 键 词：前列腺肿瘤 T-PSA F-PSA PSAD 

分 类 号：R737.25[医药卫生—肿瘤]