痔科外洗方对肛瘘创面修复TβR-β1、TGF-β1mRNA表达的影响  

Influence of Haemorrhoids Cleansing Formula on TβR-β1 and TGF-β1mRNA Expression of Anal Fistula Wound Surface Repair

作　　者：潘友珍[1] 甄金霞[1] 董青军[2] 曹永清[2] 

机构地区：[1]上海市浦东新区公利医院,上海200135 [2]上海中医药大学附属龙华医院

出　　处：《浙江中医药大学学报》2011年第6期900-901,共2页Journal of Zhejiang Chinese Medical University

基　　金：浦东新区中医领军型人才项目资助(NO:PWZI2009-05);浦东新区中医中青年骨干培养项目资助(NO:PWZJ2010-04)~~

摘　　要：[目的]探讨痔科外洗方对肛瘘创面修复的作用机理。[方法]采用动物模型,运用实时荧光定量PCR方法动态观测大鼠肉芽组织的TGF-β1水平及TGF-β1mRNA表达水平的影响,并与高锰酸钾作比较。[结果]痔科外洗方可明显提高TGF-β1水平,对TGF-β1mRNA表达有良好的调控作用,功效优于高锰酸钾。[结论]痔科外洗方对TGF-β1mRNA的良好调控作用是其对肛瘘创面的修复作用的重要机理。[Objective] To explore the functional mechanism of Haemorrhoids Cleansing Formula to anal fistula wound surface repair.[Method] Take animal model and apply real time fluorescence quantity PCR to dynamically observe rats＇ granulation tissue TGF-β1 and TGF-β1mRNA expression,compared with that of potassium permanganate.[Result] The formula can markedly improve TGF-β1 level and regulate well the TGF-β1mRNA expression,better than potassium permanganate.[Conclusion] Haemorrhoids Cleansing Formula＇s good regulation to TGF-β1mRNA is the key mechanism of its recovering fistula wound surface.

关 键 词：肛瘘 创伤修复 TGF-Β1 TGF-Β1MRNA 痔科外洗方 

分 类 号：R575[医药卫生—消化系统]