急性脑梗死溶栓治疗药物量效关系体外监测试验  

Extrinsic monitoring test of thrombolytic pharmacal dose-effect relationship in patients of acute cerebral infarction

作　　者：元小冬[1] 米振洲[2] 刘秀荣[3] 张文才[4] 袁建新[2] 王燕 裴唤珍[2] 高文静[2] 葛秀风 张萍淑[2] 刘月松 马英[2] 

机构地区：[1]华北煤炭医学院附属开滦医院神经内科唐山063000 [2]华北煤炭医学院附属开滦医院神经内科 [3]河北省开滦矿务局钱家营矿医院 [4]华北煤炭医学院科研处

出　　处：《华北煤炭医学院学报》2000年第1期4-7,共4页Journal of North China Coal Medical College

摘　　要：研究溶栓治疗时既可有效溶栓 ,又能避免出血并发症的有效用药剂量。方法　对急性脑梗死患者应用体外血栓模型试验 ,分别测定患者加入溶栓药物和未加药物对照状态下的模型及有关的指标 ,寻找加入溶栓药的体外血栓模型处于溶栓状态时的溶栓药物用量。结果　在脑梗死时自然状态下和生理盐水对照时体外血栓湿重较低 ,临床不宜进行溶栓治疗。当加入尿激酶进行溶栓试验时 ,体外血栓湿重在主干支梗死患者比穿通支梗死患者降低的更明显。结论　主干支梗死时对静脉溶栓更敏感 ,如果加入尿激酶初始量时 ,患者体外血栓处于溶栓状态 。To explore the medicament dosage with thrombolytic efliciency and avoiding the subsequent hemorrhage(SH) by extrabody thrombolytic monitoring test and the doseeffect relationship.Methods The guidelines with thrombolytic medication and without ones in extrabody thrombus model test were measured in the patients of acute cerebral infarction.The thrombolytic medicament doseage was also studied.Results The patients whose wet weight of extrabody thrombus decreased in nature and physiological salt solution control group.Patients' wet weight of extrabody chrombus reduced with main trunk infarction more than penetrating infarction when adminstering thrombolytic test with UK.Conclusions It indicated that main trunk infarction is sensitive to vein thrombolytic.If adding UK,the extrabody thrombus were in thrombolysis.We should not administer thrombolytic therapy.

关 键 词：体外血栓模型 溶栓试验 药物量效关系 

分 类 号：R743.330.5[医药卫生—神经病学与精神病学]