唑来膦酸促进口腔种植体骨结合的研究现状  

Zoledronic acid promotes osseointegration of dental implant

作　　者：谢淑娟[1] 占柳[1] 潘卫红[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院口腔科,武汉医学硕士研究生430022

出　　处：《医学研究生学报》2012年第1期76-79,共4页Journal of Medical Postgraduates

基　　金：中央高校基本科研业务费专项资金(2010JC030)

摘　　要：种植体的骨整合是目前口腔学界种植义齿的研究热点。改善种植体的骨结合,增加种植体周围的骨量,可以较好的提高种植体的稳定性,从而提高种植体成功率和延长种植体使用寿命。双磷酸盐(bisphosphonate,BPs)类药物的新生力量——唑来膦酸(Zoledronic acid),以其在BPs类药物中具有最强效的抗骨质吸收能力吸引了众多关注,在临床成功应用后,口腔专家进一步研究其在种植体方面的良好效应,通过多项实验项目观察发现其具有改善种植体骨结合的效用,并且与其他药物联合应用时可以得到更好的效果,有望投入临床,应用前景不可小觑。Osseointegration is now the focus of research on dental implant.It can improve the stability of the implant,and hence increase its success rate and prolong its life.Bisphosphonates-zoledronic acid,with its most powerful anti-bone resorption ability among bisphosphonates（BPs）,has attracted a lot of attention to the very success in its clinical application.Recently,dental experts have further studied its good effects in tooth implant by a number of pilot projects.Experiments show that it can improve osseointegration and produce better effect when combined with other drugs.

关 键 词：唑来膦酸 破骨细胞 种植体 骨结合 

分 类 号：R782.1[医药卫生—口腔医学]