Multifunctional FeCo-Graphitic Carbon Nanocrystals for Combined Imaging, Drug Delivery and Tumor-Specific Photothermal Therapy in Mice  

作　　者：Sarah P. Sherlock Hongjie Dai 

机构地区：[1]Department of Chemistry, Stanford University, Stanford, CA 94305, USA

出　　处：《Nano Research》2011年第12期1248-1260,共13页纳米研究（英文版）

摘　　要：Ultrasmall FeCo-graphitic carbon shell nanocrystals （FeCo/GC） are promising multifunctional materials capable of highly efficient drug delivery in vitro and magnetic resonance imaging in vivo. In this work, we demonstrate the use of FeCo/GC for highly effective cancer therapy through combined drug delivery, tumor-selective near-infrared photothermal therapy, and cancer imaging of a 4T1 syngeneic breast cancer model. The graphitic carbon shell of the ~4 nm FeCo/GC readily loads doxorubicin （DOX） via π-π stacking and absorbs near-infrared light giving photothermal heating. When used for cancer treatment, intravenously administrated FeCo/GC-DOX led to complete tumor regression in 45% of mice when combined with 20 min of near-infrared laser irradiation selectively heating the tumor to 43-45 ℃. In addition, the use of FeCo/GC-DOX results in reduced systemic toxicity compared with free DOX and appears to be safe in mice monitored for over 1 yr. FeCo/GC-DOX is shown to be a highly integrated nanoparticle system for synergistic cancer therapy leading to tumor regression of a highly aggressive tumor model.Ultrasmall FeCo-graphitic 碳壳 nanocrystals (FeCo/GC ) 在 vivo 在 vitro 和磁性的回声成像正在答应能够高度有效的药交货的多功能的材料。在这个工作，我们通过一个 4T1 syngeneic 乳癌模型的联合的药交货，肿瘤选择的在红外线附近的 photothermal 治疗，和癌症成像为高度有效的癌症治疗表明 FeCo/GC 的使用。4 nm FeCo/GC 的 graphitic 碳壳乐意地装载 doxorubicin (纪录影片) 经由 - 叠并且吸收给加热的 photothermal 的在红外线附近的光。当为癌症治疗使用了时，当与有选择地加热肿瘤到 4345 的在红外线附近的激光照耀的 20 min 结合了时，静脉内地管理的 FeCo/GC-DOX 在 45% 老鼠导致了完全的肿瘤回归 ??????????? 椠扭污湡散 ??????????

关 键 词：NANOCRYSTALS photothermal therapy DOXORUBICIN HYPERTHERMIA magnetic resonance imaging 

分 类 号：TQ174.12[化学工程—陶瓷工业] O482.531[化学工程—硅酸盐工业]