谷氨酰胺对肝硬化患者血清TNF-α和IL-6水平的影响  

Effect of Glutamine on Serum Tumor Necrosis Factor-α and Interleukin-6 Levels in Patients with Hepatocirrhosis

作　　者：项立[1] 胡卫东[2] 龙子义[1] 周永柏[1] 吴东海[1] 龙舟[1] 杨兵[1] 

机构地区：[1]广东省深圳市龙岗中心医院消化内科,518116 [2]广东省深圳市龙岗中心医院影像科,518116

出　　处：《中华全科医学》2012年第2期223-223,300,共2页Chinese Journal of General Practice

摘　　要：目的探讨谷氨酰胺(Gln)对肝硬化患者血清肿瘤坏死因子α(TNF-α)和白细胞介素-6(IL-6)水平的影响及临床意义。方法将44例肝硬化患者随机分为两组,对照组给予常规治疗,试验组在此基础上还给予口服L-2谷氨酰胺呱仑酸钠颗粒,治疗时间8周。对比两组患者治疗前后血清TNF-α和IL-6水平、肝功能变化及自发性腹膜炎发生率。结果试验组用Gln后血清TNF-α和IL-6水平明显降低,与对照组相比,差异有统计学意义(P<0.05),肝功能有所改善,自发性腹膜炎发生率降低,但与对照组相比,差异无统计学意义。结论谷氨酰胺可以显著降低肝硬化患者血清TNF-α和IL-6水平,有利于改善肝硬化患者的肝损害及降低并发症的发生。Objective To observe the changes in serum tumor necrosis factor-α（TNF-α） and interleukin-6（IL-6） after administration of glutamine（Gln） in patients with hepatocirrhosis.Methods Patients with hepatocirrhosis were randomized equally into 2 groups and received standard treatment.Besides,the trial group was given 8 weeks of Gln administration.The serum TNF-α,IL-6 and hepatic function were detected and spontaneous bacterial peritonitis（SAP） was observed in two groups.Results The serum IL-6 and TNF-α of Gln group decreased significantly（P0.01） in comparison with those of the control group.In Gln group,the functions of liver were improved and the incidence of SAP was lower,but it has no significance（P0.05）.Conclusion Gln may improve the clinical outcomes of patients with hepatocirrhosis probably by decreasing serum IL-8 and TNF-α.

关 键 词：谷氨酰胺 肝硬化 肿瘤坏死因子Α 白细胞介素-6 

分 类 号：R575.2[医药卫生—消化系统]