老年性痴呆患者脑神经递质与基本认知能力的典型相关分析  

Canonical correlation analysis on brain neurotransmitter and the index of basic cognition ability in patients with Alzheimer′s disease

作　　者：刘成凤[1] 张光成[1] 翟强[1] 刘洪庆[1] 李秀艳[1] 

机构地区：[1]潍坊医学院,山东潍坊261053

出　　处：《中国老年学杂志》2012年第3期451-452,共2页Chinese Journal of Gerontology

基　　金：山东省高等学校优秀青年教师国内访问学者项目(2007)

摘　　要：目的利用典型相关分析方法,探讨老年性痴呆患者的脑神经递质与基本认知能力的相互关系。方法运用分层随机抽样方法抽取潍坊市区老年性痴呆患者60名,运用脑电超慢涨落图仪测量脑电载波涨落信息,反映脑神经递质含量;基本认知能力测验软件测量7项基本认知能力。结果两组指标之间密切相关。结论老年痴呆患者两组指标中的主要指标为S5(乙酰胆碱),X3(汉字旋转效率)、X4(数字工作记忆广度)、X7(无意义图形再认),为进一步研究简化了指标体系。Objective To study the relationship between brain neurotransmitter and basic cognitive ability in patients with Alzheimer′s disease（AD） by canonical correlation analysis.Methods According to the principle of random sampling,60 patients with AD were selected.Encephaloeletricity technology was applied to measure the concentration of brain neurotransmitter.Software of basic perceive ability was applied to measure 7 basic perceive ability.Results The indexes of two groups were related significantly.Conclusions The major index are acetylcholine,character rotation efficiency,digital work memory width,nonsense graphics in patients with AD,which simplify the index system.

关 键 词：老年性痴呆 脑神经递质 基本认知能力 典型相关分析 

分 类 号：R749[医药卫生—神经病学与精神病学]