高海拔低氧环境对种植体骨结合的影响  

The influence of high-altitude and hypoxia on implant osseointegration

作　　者：李迎春[1] 肖剑锐[2] 

机构地区：[1]青海省人民医院口腔科,西宁810000 [2]解放军252医院口腔科

出　　处：《实用口腔医学杂志》2012年第1期10-13,共4页Journal of Practical Stomatology

基　　金：青海省自然科学基金资助项目(编号:2010-z-724)

摘　　要：目的:比较不同海拔高度对牙种植体周围成骨及种植体固位的影响。方法:选择广州、西宁、果洛3地区作为不同海拔地区分组,将微型种植体植入3地区饲养的兔胫骨中,通过X线观察、生物力学测试及硬组织切片法分析3地区种植体骨结合的差异。结果:X线显示,种植体植入4周时,广州组种植体周围X线骨密度最高,果洛组最低;生物力学最大拔出力(N)在4周时3组分别为194.5±4.5、176.3±6.7、165.6±2.71,12周时分别为206.7±6.5、180.5±4.8和168.3±5.2,广州组明显高于后2组(P<0.05);组织学染色分析显示,4周时3组骨接触率(%)分别为48.85±3.3、40.76±2.4和36.87±4.13(P<0.05);12周时3组骨接触率分别为50.34±5.1、41.62±2.8和39.78±3.7,广州组明显高于后2组(P<0.05)。结论:高海拔低氧环境影响种植体的骨结合。Objective： To compare the bone formation and the retention of the implant at different altitude.Methods： Implants were inserted in the tibia of rabbits in three different altitude areas：Guangzhou-42 m,Xining-2,275 m and Guoluo-3 780 m above the sea level（n=8）,the bone-implant osseointegration was examined by roentgenocopy,biomechanical test and ponceau staining 4 and 12 weeks after implantation respectively.Results： X-ray films showed higher bone density around the implants in Guangzhou group than that in the other two groups 4 weeks after implantation.The Max biomechanical pull-out forces（N） were 194.5±4.5,176.3±6.7,165.6±2.71 four weeks after and 206.7±6.5,180.5±4.8,168.3±5.2 twelve weeks after implantation respectively in Guangzhou,Xining and Guoluo groups respectively（P0.05）.Ponceau staining showed that the bone-implant-contact（%） were 48.85±3.3,40.76±2.4 and 36.87±4.13 four weeks after（P0.05）,and 50.34±5.1,41.62±2.8 and 39.78±3.7 twelve weeks after implantation respectively（P0.05）.Conclusion： Higher altitude with lower oxygen may decrease bone-implant osseointegration.

关 键 词：牙种植 海拔高度 低氧环境 生物力学 骨接触率 

分 类 号：R783.6[医药卫生—口腔医学]