HGF/c-met在口腔黏膜下纤维化组织中表达的研究  

Expression of HGF and c-met in oral submucous fibrosis

作　　者：张姗姗[1] 凌天牖[1] 

机构地区：[1]中南大学湘雅二医院口腔医学中心,长沙410011

出　　处：《实用口腔医学杂志》2012年第1期110-113,共4页Journal of Practical Stomatology

摘　　要：收集早、中、晚期口腔黏膜下纤维性变(oral submucous fibrosis,OSF)组织各10例及正常的口腔颊黏膜组织5例,采用免疫组化SABC法对各种组织中的HGF及c-met的表达情况进行检测。结果显示在正常的口腔颊黏膜组织中HGF和c-met呈阳性表达,早、中、晚期OSF组织中表达明显降低(P<0.05)。说明HGF/c-met在OSF组织中表达受到抑制,促进了OSF的发病。The immunohistochemical SABC method was used to detect the expression and distribution of HGF and c-met in 5 heathy controllers and 30 cases of oral submucous fibrosis（OSF）.The positive expression of HGF and c-met was found in normal oral mucosa and a significant decrease of the expression was observed in early,intermediate and advanced stages of OSF（P0.05）.Reduction of HGF and c-met expression may contribute to the pathogenesis of OSF.

关 键 词：口腔黏膜下纤维化 肝细胞生长因子 肝细胞生长因子受体 免疫组织化学 

分 类 号：R781.5[医药卫生—口腔医学]