肥胖与前列腺癌关系的Meta分析  

Meta-analysis of obesity and prostate cancer

作　　者：向安莉[1] 冯加武[1] 叶华容 常勇[1] 叶方立[1] 

机构地区：[1]武汉科技大学医学院流行病与统计学教研室,湖北省武汉市430065

出　　处：《职业与健康》2012年第2期154-156,共3页Occupation and Health

摘　　要：目的探讨肥胖致前列腺癌的因果关系,为前列腺癌的预防和病因研究提供参考依据。方法分别用"肥胖"、"前列腺癌"、"Meta分析"中的英文检索词检索中国期刊网、Science Direct、Springer Link、等数据库,检索近10年公开发表的有关肥胖与前列腺癌的研究文献,分别采用RevMan 5.0软件中的分类数据和一般反向方差法进行Meta分析。结果纳入该次分析的文献共有6篇,累计病例3 328例,对照535 724例。单项研究的OR值范围为0.78～1.31,合并OR值为1.11,95%可信区间为1.01～1.23。结论病例对照文献提示前列腺癌与肥胖存在联系。[Objective]To discuss the cause-effect relationship between obesity and prostate cancer,and provide reference for prostate cancer prevention and its etiological study.[Methods]Case-control studies about obesity and risk of prostate cancer were identified for a meta-analysis by searching ScienceDirect,Springer Link and China Full Text Journal databases from 2001-2010 by using the search terms ＇obesity＇,＂prostate cancer＂,＂Meta-analysis＂.The meta-analysis was performed by disaggregated data and general reverse variance method in RevMan 5.0.[Results]A total of 6 articles were included in this study,with 3 328 cases and 535 724 controls.The OR value for individual studies ranged from 0.78-1.31.The pooled OR was 1.11 with 95% confidence interval（CI） of 1.01-1.23..[Conclusion]The case-control articles indicates that prostate cancer appear to be related to obesity.

关 键 词：肥胖 前列腺癌 META分析 

分 类 号：R737.25[医药卫生—肿瘤]