β-连环蛋白与抑癌基因ING1蛋白在肺癌组织中的表达  

Expression and its clinical signification ofβ-catenin and anti-oncogene ING1 in lung carcinoma tissues

作　　者：曾凡军[1,2] 周媛媛[1,2] 宋新宇[1,2] 熊晓琦[1,2] 赵必君[1,2] 陈世雄[1,2] 

机构地区：[1]三峡大学第一临床医学院 [2]宜昌市中心人民医院呼吸内科,湖北宜昌443003

出　　处：《疑难病杂志》2012年第2期110-112,F0003,共4页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的观测β-连环蛋白(β-catenin)及抑癌基因ING1的蛋白表达产物p33^(ING1)在肺癌中的表达。方法纳人40例肺癌组织标本(肺癌组)和10例正常肺组织标本(对照组),采用免疫组化SP法检测β-catenin及p33^(ING1)蛋白在2组中的表达,并分析p33^(ING1)蛋白表达与肺癌临床病理特征的关系。结果肺癌组和对照组p33^(ING1)阳性表达率分别为57.5%和100.0%,2组差异有统计学意义(P<0.05)。肺癌组中β-catenin阳性表达率为81.2%,异常表达率为64.4%,p33^(ING1)与β-catenin阳性表达率呈正相关(r=0.6324,P<0.05)。p33^(ING1)表达与性别、年龄、病理组织学类型等无关(P>0.05),而与分化程度、TNM分期、有无淋巴结转移等有关(P<0.05)。结论β-eatenin的异常表达及p33^(ING1)表达与肺癌发生发展密切相关;联合检测其表达水平的变化对肺癌的早期诊断、恶性程度判断及基因介导治疗等方面均有重要指导意义。Objective To investigate theβ-catenin(β-catenin) and the protein expression of anti-oncogene ING1 in lung cancer.Methods Immunohistochemical SP method was used to detect theβ-catenin and p33^(ING1)protein in 40 samples of lung cancer and 10 normal lung tissues,and analyzed the relationship between p33^(ING1)protein expression and pathological character of lung cancer.Results p33^(ING1)protein positive expression rate in lung cancer and normal lung tissues were 57.5% and 100.0%,respectively,there was statistical differences(P<0.05).Positive rate of expression ofβ-catenin in the 40 samples of lung cancer was 81.2%,abnormal expression rate was 64.4%,there was positive correlation between p33^(ING1)and P-catenin positive expression rate(r=0.6324,P<0.05).There were no relationship between p33^(INC1)expression and sex, age and pathological type of the disease(P>0.05),but there were correlation between differentiation degree,TNM stage and nodal metastasis(P<0.05).Conclusion There are close relationship between development of lung cancer and the abnormal expression of p-catenin and p33.It is important to detect the both expression levels of the p-catenin and p33^(ING1) for the early diagnosis of lung cancer,determine the degree of malignancy and gene mediated therapy.

关 键 词：肺肿瘤 Β-连环蛋白 抑癌基因ING1 p33~ING1蛋白 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]