血管内皮细胞-平滑肌细胞共培养体系研究进展  

Advance in study of vascular endothelial cell and smooth muscle cell co-culture system

作　　者：李玉洁[1] 杨庆[1] 翁小刚[1] 陈颖[1] 阮从潇[1] 李丹[1] 朱晓新[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国中药杂志》2012年第3期265-268,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金面上项目(30973901);国家"重大新药创制"科技重大专项(2009ZX09301-005-2-4);中国中医科学院自主选题项目(ZZ20090207)

摘　　要：血管内皮细胞(endothelial cells,EC)和血管平滑肌细胞(smooth muscle cells,VSMC)的相互作用、相互影响维持血管生理功能和多种疾病的发生发展,EC-SMC联合培养模型是目前研究这2种细胞间相互影响的最佳方式。作者对现有的EC-SMC共培养模型及共培养对这2种细胞结构和功能的影响进行综述,为在微观上深入研究二者的相互关系提供依据,也为建立更接近机体生理/病理状态的EC-SMC体外共培养体系提供参考。The interactions between endothelial cells （EC） and smooth muscle cells （SMC） contribute to vascular physiologi- cal functions and also cause the occurrence and development of different kinds of diseases. Currently, EC-SMC co-culture model is the best way to study the interactions between the two kinds of cells. This article summarizes existing EC-SMC co-culture models and their effects on the structure and functions of the two kinds of ceils. Microscopically speaking, it provides a basis for in-depth studies on their interactions as well as a reference for the establishment of in vitro EC-SMC co-culture system that is closer to organic physiology or pathology state.

关 键 词：内皮细胞 平滑肌细胞 共培养 相互作用 

分 类 号：R363[医药卫生—病理学]