检测胃癌血清和腹水中CA72-4抗原水平的临床意义  

Clinical significance of CA72-4 antigen levels In serum and peritoneal washing for gastric carcinoma

作　　者：孙萍[1] 盛家和[1] 王征帆[1] 

机构地区：[1]河南省肿瘤医院检验科,郑州市450000

出　　处：《实用医学杂志》2012年第3期480-482,共3页The Journal of Practical Medicine

摘　　要：目的:对胃癌患者进行CA72-4含量的检测,分析血清和腹水中的CA72-4水平与胃癌的相关性,预期判定腹膜复发的可能性。方法:研究了48例胃癌患者血清和腹水中的CA72-4水平、损伤部位及根除和淋巴结转移的数量。结果:淋巴结转移的胃癌患者与血清和腹水中的高水平CA72-4含量显著相关。浆膜浸润胃癌与血清中的CA72-4水平含量无显著统计学相关性,然而,与腹水中的CA72-4水平含量显著相关。尽管血清中的CA72-4水平含量与晚期胃癌无显著相关性,但腹水中的CA72-4水平含量与晚期胃癌呈显著相关。结论:腹水中的CA72-4高水平含量与淋巴结转移和浆膜浸润胃癌显著相关。血清中的CA72-4水平含量仅与淋巴结转移相关,与浆膜浸润胃癌无显著相关。Objective To detect the content of CA72-4 antigen in ascites of gastric carcinoma patients, CA72-4 levels in serum and aseitic fluid were detected, the relationship between gastric cancer and CA72-4 levels was determined, the possibility of of recurrence in peritoneum was evaluated. Method CA72-4 levels in serum and ascites in 48 cases with gastric cancer were detected, injury site and the number of eradicated metastatic lymph node were documented. Result High content of CA72-4 in serum and aseites of patients was associated with lymph node metastasis of gastric cancer. No significance statistically was found between serum CA72-4 level and serosal invasion of gastric cancer, however, the level of CA72-4 in ascites was associated with serosal invasion of gastric cancer. Although serum CA72-4 level in serum was not correlated with advanced gastric cancer, CA72-4 level of in ascites of patients was not correlated with advanced gastric cancer. Conclusions CA72-4 high level in aseites were correlated with serosal invasion and lymph node metastasis of gastric cancer. Serum CA72-4 level was only associated with lymph node metastasis, but was not associated with serosal invasion of gastric cancer.

关 键 词：胃肿瘤 肿瘤标志物 CA72-4 

分 类 号：R735.2[医药卫生—肿瘤]