乳香提取物对大鼠乙酸胃溃疡愈合质量的影响研究  

Study of the effect of Frankincense extraction on ulcer healing quality in gastric ulcerated rats

作　　者：梅武轩[1] 曾常春[2] 

机构地区：[1]咸宁学院医学院,湖北咸宁437100 [2]华南师范大学信息光电子科技学院,广东广州510631

出　　处：《现代中西医结合杂志》2012年第5期478-479,486,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：湖北省教育厅中青年项目(Q20092804);湖北省教育厅重点项目(D20112807)

摘　　要：目的探讨乳香提取物对大鼠乙酸胃溃疡愈合质量的影响及OCT技术应用于溃疡愈合质量研究的价值。方法用冰醋酸制备大鼠慢性胃溃疡模型,随机分为4组,分别灌服生理盐水、乳香提取物、奥美拉唑等。用病理及OCT技术对再生黏膜厚度进行动态观察。结果乳香提取物组再生黏膜厚度增加,OCT可以检测到溃疡病灶黏膜下层组织的愈合过程。结论乳香提取物能提高溃疡再生黏膜结构成熟度,提高溃疡愈合质量,OCT对愈合质量的研究具有一定的价值。Objective It is to explore the effect of Frankincense extraction on ulcer healing quality in gastric ulcerated rats,and to explore the application value of pathology and optical coherence tomography（OCT） device for the ulcer healing quality study.Methods The rat model of chronic gastric ulcer was established by acetic acid,then they were randomly divided into four groups,fed with normal saline,frankincense extracts and omeprazole and so on respectively.The thickness of regenerative mucosa was dynamic observed by pathology and OCT technology.Results The thickness of regenerative mucosa of frankincense extract group was significantly thicker than that of other groups,OCT could dynamic observed the submucosa tissue ulcer healing.Conclusion Frankincense extract can improve the regeneration of mucosal ulcers maturity structure,improve the quality of ulcer healing,OCT has a certain value for determining their quality？of healing.

关 键 词：乳香提取物 胃溃疡 光学相干层析成像 再生黏膜 

分 类 号：R-332[医药卫生]