青藤碱与羟丙基-β-环糊精的包合作用  

Characterization of Inclusion Complex of Sinomenine into Hydroxypropyl-β-cyclodextrin

作　　者：朱士龙[1,2] 陈迪钊[1,3] 李勇[2] 林红卫[1,3] 段友构[2] 

机构地区：[1]怀化学院化学化工系,湖南怀化418008 [2]吉首大学化学化工学院,湖南吉首416000 [3]民族药用植物资源研究与利用湖南省重点实验室,湖南怀化418008

出　　处：《精细化工》2012年第2期159-163,208,共6页Fine Chemicals

基　　金：湖南省自然科学基金资助项目(06JJ50020);湖南省教育厅资助项目(09C760);民族药用植物资源研究与利用湖南省重点实验室开放基金项目(HHUW2010-68);吉首大学校级科研项目(11JDY052)~~

摘　　要：通过溶液共混法制备青藤碱-羟丙基-β-环糊精包合物,纯化后利用体视显微镜观察包合物的结晶形态,通过差热示重扫描、红外光谱、X射线粉末衍射及核磁共振波谱等方法对包合物进行性质分析,并通过相溶解度法计算包合物的包合常数。结果表明,青藤碱、羟丙基-β-环糊精包合后性质发生明显变化,羟丙基-β-环糊精能显著增加青藤碱的溶解度,包合物中青藤碱与羟丙基-β-环糊精包合分子个数比为1∶1,其包合常数为150.0 L/mol,反应的吉布斯自由能为-12.41 kJ/mol。The inclusion complex of sinomenine （SN） into hydroxypropyl-β-cyclodextrin （ HP-fl-CD ） was prepared successfully through mixed solution method. The crystalline morphology and micromorphology of the inclusion complex was characterized and analyzed by means of stereomicroscope after purification and recrystallization. Other material behaviors of the inclusion complex of sinomenine into HP-β-CD were characterized through X-ray diffraction （XRD）, infrared spectrography （IR）, differential scanning calorimetry （DSC） and hydrogen nuclear magnetic resonance（ HNMR）, and then the formation constant of the inclusion complex was determined by phase solubility analysis. The results indicate that, compared to SN, the inclusion complex of SN into HP-fl-CD showed obvious changes in characteristics. The inclusion complex of SN into HP-β-CD was a new material form and HP-β-CD could sharply increase the solubility of SN. The molecular ratio of SN to HP-β-CD was 1：1, the inclusion constant was calculated to be 150. 0 L/mol and the Gibbs free energy of the complexation was - 12. 41 kJ/mol.

关 键 词：青藤碱 羟丙基-Β-环糊精 包合物 X射线粉末衍射 差热分析 红外光谱 核磁共振氢谱 医药原料 

分 类 号：TQ464.4[化学工程—制药化工]