TNF-α、TNF-β和NF-κBp50在不同类型淋巴瘤的表达及其意义  

Expression of TNF-α,TNF-β and NF-κBp50 and their significances in subtypes of lymphoma

作　　者：陈海霞[1] 吴文华[2] 顾霞[1] 马瑞[1] 王欣[1] 郭新红[3] 

机构地区：[1]新疆医科大学第一附属医院病理科,乌鲁木齐830011 [2]新疆医科大学第一附属医院信息档案科,乌鲁木齐830011 [3]新疆医科大学第一附属医院血液科,乌鲁木齐830011

出　　处：《新疆医科大学学报》2012年第1期37-43,共7页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(30860096)

摘　　要：目的探讨肿瘤坏死因子α(Tumor necrosis factorα,TNF-α)、肿瘤坏死因子β(Tumor necrosis factorβ,TNF-β)与核因子κBp50(Nuclear factor ofκappa Bp50,NF-κBp50)在不同类型淋巴瘤中的表达及其意义。方法收集97例不同类型淋巴瘤患者石蜡组织和5例反应性增生淋巴结组织标本,应用免疫组织化学方法观察组织中TNF-α、TNF-β与NF-κBp50表达情况。结果 TNF-α、TNF-β与NF-κBp50在霍奇金淋巴瘤(HL)和非霍奇金淋巴瘤(NHL)中均有不同程度的表达。TNF-α在淋巴母细胞淋巴瘤(LBL)与周围T细胞淋巴瘤(PTL)、LBL与浆细胞肿瘤(PCN)组间表达差异有统计学意义(P<0.05),其它各亚型组间的差异无统计学意义(P>0.05);TNF-β与NF-κBp50在淋巴瘤各亚型之间的表达差异无统计学意义(P>0.05);TNF-α表达和淋巴瘤临床病理特征差异均无统计学意义(P>0.05);TNF-β表达在国际预后指数(IPI)评分的中-高危组高于低危组,组间差异有统计学意义(P<0.05),其余各组之间的差异无统计学意义(P>0.05);NF-κBp50表达在汉族和少数民族之间差异有统计学意义(P<0.05),其余各组之间的差异无统计学意义(P>0.05);TNF-α、TNF-β及NF-KBp50蛋白表达无相关性(P>0.05)。结论 TNF-α、TNF-β与NF-κBp50在不同类型淋巴瘤组织中均有不同程度的表达,在淋巴瘤的发生、发展中可能起着一定作用;TNF-β表达与IPI评分的中-高危组有关,提示其对淋巴瘤预后判断有一定的参考价值。Objective To investigate the expression of tumor necrosis factor α（TNF-α factor β （TNF-β） and Nuclear factor of Kappa BpS0 （NF-kBpS0） and its significance ma. Methods Immunohistochemical technique was used to assess the expression NF-kBp50 in 97 cases paraffin tissue of subtypes of lymphoma and 5 cases of lymph node necrosis btypes of lympho- of TNF-a, TNF-β and node re Results Expression level of TNF-a, TNF-β and NF-kBpS0 were different in HI. and active prolifera NHL. Expression of TNF-a in lymphoblastic lymphoma （LBL） and proliferstive T cell lymphoma （PTL）, lymphoblastic lymphoma （LBL） and plasma cell tumor （PCN） had significant difference （P d0.05）, others group had no significant difference （P 〉0.05） Expression of TNF-β and NF-xBp50 in subtypes of lymphoma was not significant different （P 〉0.05）. Expression of TNF-β had significant difference between low-risk group and middle-high risk group of International Prognosis Index （P 〈0.05）, the expression of others group was not significant different （P 〉0.05）. Expression of TNF-a, TNF-β and NF-xBp50 in subtypes of lym- phoma had no correlation （P 〉0.05）. Conclusion TNF-a, TNF-α and NF-xBp50 had been found various degree expression in subtypes of lymphoma, TNF-a, TNF-α and NF-xBp50 play roles in the development of lymphoma. Expression of TNF-β have has associated with of middle-high risk group of International Prognosis Index. It has a certain reference value in the prognosis of lymphoma.

关 键 词：淋巴瘤 TNF-Α TNF-Β NF-ΚBP50 免疫组化 

分 类 号：R739.8[医药卫生—肿瘤]