芪麝颈康丸对颈椎间盘内IL-1α、IL-6、TNFα含量的影响  

Experimental Study The Effect of Qishejingkang Recipe on IL-1α、 IL-6、TNFα of Degenerated Cervical Vertebral of Rabbits

作　　者：王拥军[1] 施杞[1] 石印玉[1] 吴士良[2] 沈培芝[1] 徐宇[1] 刘梅 

机构地区：[1]上海市中医药研究院骨伤科研究所,上海200032 [2]苏州医学院生化教研室

出　　处：《中国中医骨伤科杂志》2000年第1期23-25,共3页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：上海市科学技术发展基金!(NO:964919019)

摘　　要：目的：了解退变颈椎间盘的病理变化过程，检测退变椎间盘内细胞因子含量，并观察芪麝颈康丸对其抑制作用。方法：首先建立家兔静力失衡性颈椎病动物模型，诱导兔颈椎间盘退变，分对照组与模型组及治疗组，双抗夹心ＥＬＡＳＡ技术检测各组动物椎间盘中ＩＬ－１α、ＩＬ－６、ＴＮＦα抗体含量，进行组间比较。结果：７月造模组与对照组相比较，椎间盘中ＩＬ－１α、ＩＬ－６、ＴＮＦα含量均明显升高，有统计学差异，而芪麝颈康丸对其含量有降低作用（Ｐ＜０．０１）。结论：退变椎间盘中释放的细胞因子可以加速炎症介质的释放，加速椎间盘的退变，芪麝颈康丸对其含量有明显的抑制作用。To study the effect of Qishejingkang recipe on contents of IL 1α、IL 6、TNFα of degenerated cervical vertebral. A model of degenerated cervical vertebral in the rabbit was established through resection of the cervical supraspinous and interspinous ligaments from the cervical spine elicited by surgical intervention. The contents of IL 1α、IL 6 and TNFα in disc of degenerated cervical vertebral was assayed with ELASA. The contents of IL 1α、IL 6 and TNFα in disc of degenerated cervical vertebral in Qishejingkang recipe group declined significantly compared with model group. Qishejingkang Recipe could decrease the content of IL 1α、IL 6 and TNFα in disc of degenerated cervical vertebral and it might inhabited the formation of inflammatory effect.

关 键 词：芪麝颈康丸 颈椎 椎间盘退变 IL-1Α IL-6 TNFΑ 

分 类 号：R274.915[医药卫生—中西医结合]