慢性肝病患者血清可溶性细胞间粘附分子-1、白细胞介素-8及肿瘤坏死因子-α水平及临床意义  

Clinical significance and serum levels of sICAM-1, IL-8 and TNF-α in patients with chronic hepatic disease

作　　者：申星杰[1] 

机构地区：[1]济南市中心医院消化内科,250013

出　　处：《中国实用医刊》2012年第4期1-3,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨可溶性细胞间粘附分子-1（sICAM-1）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF—α）与慢性肝脏疾病的关系。方法采用酶联免疫吸附试验（ELISA）检测132例慢性肝病患者及30例健康对照组血清sICAM-1、IL-8及TNF-α含量，同时用放射免疫法测定测定透明质酸（HA）水平，并进行相关性分析。结果慢性肝病患者血清sICAM-1、IL-8、TNF—α和HA水平明显高于对照组，差异有统计学意义（P〈0．05）。血清sICAM-1、IL-8及TNF—α与HA呈显著正相关（P〈0．05）。结论sICAM-1、IL-8及TNF-α是肝纤维化非创伤性诊断的血清学指标，它们与HA水平呈正相关。提示sICAM-1、IL-8及TNF-α可作为反映慢性肝病患者肝纤维化以及肝损伤程度的指标。Objective To investigate the correlation between sTCAM-1, IL-8 and TNF-α and chronic liver diseases. Methods The serum levels of sICAM-1, IL-8 and TNF-α were measured by ELISA in 132 cases of chronic hepatitis and 30 healthy controls. The serum levels of HA was measured by RIA. All results were conducted by correlative analysis. Results The serum levels of sICAM-1, IL-8, TNF-α and HA in patients with chronic liver diseases were significantly higher than those in control group （P 〈 0.05）. sICAM-I,IL-8 and TNF-α were positively correlated with HA （P 〈 0.05）. Conclusions The serum sICAM-1, IL-8 and TNF-α paticipated in the development of chronic liver fibrosis and might be considered as the serum standards of diagnosing. The serum sICAM-1, IL-8 and TNF-α were positively correlated with HA. It indicates that serum sICAM-1, IL-8 and TNF-α are good indexes to reflect the degree of liver fibrosis in patients with chronic liver diseases.

关 键 词：慢性肝病 可溶性细胞间粘附分子-1 白细胞介素-8 肿瘤坏死因子-Α 透明质酸 肝纤维化 

分 类 号：R575[医药卫生—消化系统]