经肝动脉灌注莪术油微球对大鼠移植性肝癌的治疗作用  

Therapeutic efficacy of microsphere-entrapped curcuma aromatica oil infused via hepatic artery against transplanted hepatoma in rats

作　　者：吴万垠 邓嵘 区勇全 邓时贵 莫莉莉 

机构地区：[1]广州中医药大学第二附属医院肿瘤科,510120

出　　处：《中华肝脏病杂志》2000年第1期24-26,共3页Chinese Journal of Hepatology

基　　金："九五"国家科技攻关课题基金!96-906-07-04;广东省自然科学基金! 980663

摘　　要：目的观察莪术油微球经肝动脉灌注对大鼠移植性肝癌的治疗作用。方法复制１００只大鼠移植性肝癌模型，随机分为对照组、莪术油组、空白做球组、高剂量和低剂量莪术油微球组，每组２０只。经胃十二指肠动脉至肝固有动脉分别灌注生理盐水０．２～０．３ｍｌ、 莪术油１０ｍｇ／ｋｇ、空白微球１０ｍｇ／ｋｇ及高低剂量莪术油微球１０ｍｇ／ｋｇ和５ ｍｇ／ｋｇ。比较各组大鼠生存时间及肿瘤生长情况和坏死程度。结累与对照组比较，高低剂量莪术油微球治疗组大鼠的肿瘤生长率均受到显著抑制门（１．２３％±０．６６％，４．８６％±１４．７％对２２．４４％±１７．８１％，Ｆ＝１０．２５，Ｐ＜０．０１），肿瘤坏死以重度为主，生存时间亦明显延长（２５．５０ ｄ±３．８９ ｄ，２２７０ ｄ±３．９２ ｄ对１１．７０ｄ±１．８９ｄ，Ｆ＝３６．５３，Ｐ＜０．０１）。莪术油微球的作用优于莪术油或空白微球。结论经肝动脉灌注莪术油微球较灌注莪术油或空白微球对大鼠移植性肝癌具有更好的治疗作用。 【Objective To observe the therapeutic efficacy of microsphere-entraPPed Curcuma aromahca oil(MSCAO) infused via hepatic artery against transplanted hepatoma in rats. Methods One hunthed duplicated rats bearing transplanted hepatoma were randomly divided into control group, CAO group, blank ndcrosphere(B-MS) group, high-dose and lowdose MS-CAO groups. Each group included twenty rats. NOrmal saline(0.2-0.3 Inl), CAO(10 mg/kg), B-MS (10 mthe) and MSCAO(10 mglkg, 5 mghg) were infused from gastroduodenal artery into hepatic artery, in five groups of rats respectively. The survival periods and the tumor growth rates and necrosis grades were compared in rats among five groups. Results Compared with the control group of rats, the tumor growth rates were significantly inhibited (l.23% 1 0.66%, 4.86% t l.47% vs 22.44% ; 17.81%, F = 10.21, P < 0.01), the tumor necrosis grades were more extensive (He = 23.63, P < 0.01) and the survival periods were also prolonged (25.50 d, 1 3.89 d, 22.70 d , 3.92 d vs 1 1 .70 d I I .89 d, F = 36.53, P < 0.01) in either highdose or low-dose MS-CAO group. The therapeutic effects of MS-CAO were superior to either CAO or B-MS. Conclusion The therapeutic efficacy of MS-CAO infused via hepatic artery against hepatoma was much better than that of CAO or BMS in the rats beding thansplanted hapatoma.

关 键 词：肝肿瘤 肝动脉 莪术油 灌注疗法 大鼠 

分 类 号：R73-36[医药卫生—肿瘤]