肝细胞癌根治性切除术后预后影响因素的分析  

Analysis of prognostic factors in hepatocellular carcinoma subsequent to radical resection

作　　者：李华[1] 潘承恩[1] 刘青光[1] 王欣璐[2] 

机构地区：[1]西安医科大学第一临床医学院肝胆外科 [2]西安医科大学第一临床学院影像中心,陕西西安710061

出　　处：《中国普通外科杂志》2000年第1期55-58,共4页China Journal of General Surgery

摘　　要：目的　探讨肝细胞癌(HCC)患者根治性切除后的主要预后影响因素。方法　对56例经根治性切除的患者进行回顾性统计,应用Cox比例风险模型对可能影响预后的16项指标进行了多因素分析,并建立生存预测方程。结果　本组1,3,5年生存率分别为8973%,5408%,2912%。影响肝癌预后最明显的因素是门静脉癌栓、Cmyc表达及肿瘤无包膜。生存预测方程总X2=53281,P<0.001。按预后指数分组,低危组、中危组及高危组间5年生存率具显著性差异(P<0.005)。结论　肝细胞癌预后由多种因素决定,对于低危组及中危组患者,应积极手术治疗以期获得较好疗效。Objective To evaluate the major prognostic factors in hepatocellular carcinoma (HCC) subsequent to radical resection. Methods Retrospective analysis of 16 factors for prognosis were studied by multivaritate analysis with Cox proportional hazard model in 56 cases of HCC treated by radical resection, and a survival prediction equation was also established. Results In this series, the survival rates of 1,3 and 5 years were 89.73%, 54.08% and 29.12% respertively. The most signficant prognostic factors were tumor thrombus in the portal vein, C myc gene expression and tumor without capsule. The survival prediction equation was X 2=53.281 P<0.001. A five year survival rates was significants different (P<0.05) among patients in low, intermediate and high risk group divided by prognostic index. Conclusions The prognosis of HCC is determined by varied factors. For the low and intermediate risk patients, surgical treatment is strongly recommended so as to improve the prognosis.

关 键 词：肝肿瘤/外科学 肝细胞瘤/外科学 预后 

分 类 号：R735.7[医药卫生—肿瘤]