MUC1,MUC2和MUC3在胃增生性息肉中的表达模式  

Expression patterns of MUC1, MUC2 and MUC3 in gastric hyperplastic polyps

作　　者：李娟[1] 吴丽华[1] 石岩[1] 焦宇飞[1] 

机构地区：[1]哈尔滨医科大学附属第二临床医院病理科,黑龙江省哈尔滨市150081

出　　处：《世界华人消化杂志》2011年第35期3591-3596,共6页World Chinese Journal of Digestology

摘　　要：目的:研究MUC1,MUC2和MUC3在胃增生性息肉(gastric hyperplastic polyp,GHP)中的表达模式,旨在发现可以提示GHP发生癌变的有价值的标志物.方法:选用明确诊断的经手术切除或胃镜活检的GHP标本238例,其中包括GHP未伴有不典型增生188例,GHP伴低级别不典型增生(low grade dysplasia,LGD)35例,GHP伴高级别不典型增生(high grade dysplasia,HGD)8例及GHP伴局灶癌变(carcinoma,Ca)7例.同时选取30例正常胃黏膜标本为正常对照.采用免疫组织化学方法评价MUC1,MUC2及MUC3的阳性表达百分率及其表达模式.结果:MUC1呈现2种表达模式.模式1:细胞质和细胞膜弥漫阳性;模式2:腔缘侧细胞膜阳性.所有正常的胃黏膜和85.6%的未伴有不典型增生的GHP,MUC1表达呈模式1.80%的GHP伴LGD和100%的GHP伴高级别不典型增生或癌变(HGD/Ca)其MUC1的表达呈模式2(P<0.001).MUC2在GHP中表达阳性率为8.11%,GHP伴LGD为21.93%,GHP伴HGD/Ca为31.42%(P<0.001).MUC3仅在1例GHP伴LGD和3例GHP伴HGD/Ca中表达阳性.结论:MUC1和MUC2可能是提示GHP具有恶变潜能的有价值的标志物.AIM： To evaluate the expression patterns of MUC1, MUC2 and MUC3 in gastric hyperplastic polyps （GHP） and to analyze their value as markers for judging the malignant potential of GHP. METHODS： A total of 238 GHP biopsy or surgical specimens, including 188 cases without dysplasia, 35 cases with low grade dysplasia （LGD）, 8 cases with high grade dysplasia（HGD）, and 7 cases with carcinoma （Ca）, were used in this study. Thirty normal gastric mucosal specimens were used as controls. Immunohistochemistry was performed to detect the expression patterns of mucin proteins （MUC1, MUC2 and MUC3） in these specimens. RESULTS： Cytoplasmic and membranous expression of MUC1 was observed in 85.60% of GHP cases without dysplasia or carcinoma. Glandular luminal expression of MUC1 was observed in 80.0% of GHP cases with LGD and 100% of GHP cases with HGD/Ca. The positive rate of MUC2 expression was 8.11% in GHP, 21.93% in GHP with LGD, and 31.42% in GHP with HGD/ Ca. MUC3 expression was detected in one case of GHP with LGD and three cases of GHP with HGD/Ca but not in GHP without dysplasia. CONCLUSION： MUC1 and MUC2 may be useful markers for judging the malignant potential of GHP.

关 键 词：胃增生性息肉 粘蛋白 表达模式 

分 类 号：R735.2[医药卫生—肿瘤]