乳腺癌的分子分型与肿瘤治疗的相关性  

A comprehensive view over breast cancer molecular subtypes and to provide foundation for treatment strategy

作　　者：侯净[1] 郭小毛[1] 冯炎[1] 

机构地区：[1]复旦大学上海医学院肿瘤学系,复旦大学附属肿瘤医院放疗科,上海200032

出　　处：《中国癌症杂志》2011年第11期882-888,共7页China Oncology

基　　金：国家自然科学基金(No:81072164)

摘　　要：乳腺癌是女性最常见的肿瘤之一,因其肿瘤组织具有高度异质性、多种组织亚型,因而产生不同临床表现、不同治疗反应以及不同预后。传统评价乳腺癌预后的因素包括:发病年龄、肿瘤大小、临床分期、淋巴结转移等。近年来,基于基因表达谱不同提出的乳腺癌分子分型研究不断深入,为乳腺癌的个体化治疗提供了一个有力的依据。本文从乳腺癌的固有分子分型入手,描述不同分子分型的特点及其临床结局的差异,着重阐述不同分子分型与乳腺癌局部复发的关系,同时对其他分子分型进行简要分析,以期对乳腺癌分子分型有一个全面的了解并为临床治疗方案的制定提供依据。Breast cancer is one of the most common tumors of women,with different clinical presentations, treatment responses and outcomes due to high heterogeneity and various histological subsets.The conventional factors evaluating its prognosis includes age at diagnosis,primary tumor size,histological grade,axillary lymph node status and the like.In recent years,the researches about molecular subtypes of breast cancer divided according to gene expression profiling have become more detailed,providing a powerful clue for individual treatment.In this review,we start with describing characteristics and clinical outcomes of different intrinsic subtypes,then focus on the correlation between intrinsic subtypes and locoregional recurrence.In addition,we give a brief analysis for other molecular types,so as to draw a comprehensive view over breast cancer molecular subtypes and to provide foundation for treatment strategy.

关 键 词：乳腺癌 分子分型 局部控制 复发 

分 类 号：R737.9[医药卫生—肿瘤]