治疗前血红蛋白水平对鼻咽癌患者调强放疗预后的影响  

Influence of Preradiation Hemoglobin Level on the Prognosis of Patients with Nasopharyngeal Carcinoma(NPC)after Intensity-Modulated Radiation Therapy

作　　者：陈希[1,2] 马礼钦[1,2] 胡彩容[1,2] 潘才住[1,2] 潘建基[1,2] 

机构地区：[1]福建医科大学省立临床医学院 [2]福建医科大学教学医院福建省肿瘤医院,350014

出　　处：《实用癌症杂志》2012年第1期41-44,共4页The Practical Journal of Cancer

基　　金：福建省科技计划重点项目(编号:2009Y0013)

摘　　要：目的探讨治疗前血红蛋白水平(HBC)对鼻咽癌患者(NPC)调强放疗(intensity-modulated radiation thera-py,IMRT)预后的影响。方法将250例鼻咽癌患者,根据放疗前血红蛋白水平分为3组(HBC<120 g/L组,HBC 120～150 g/L组,HBC≥150 g/L组)。结果 HBC<120 g/L、HBC 120～150 g/L、HBC≥150 g/L 3组3年局控率分别为92.9%、94.6%和93.2%,3年无远处转移生存率分别为92.9%、85.1%和90.0%,3年无瘤生存率分别为64.3%、76.4%和86.4%(P<0.01),3年总生存率分别为78.6%、83.8%和94.3%(P<0.01)。COX回归分析结果表明,治疗前血红蛋白水平是影响鼻咽癌患者预后的独立因素。结论 NPC患者放疗前HBC>150 mg/L,是影响患者无瘤生存率及总生存率的独立因素。Objective To explore the influence of preradiation peripheral blood hemoglobin concentration on the prognosis of patients with nasopharyngeal carcinoma（NPC）after radiotherapy.Methods Clinical and follow-up data of 250 NPC patients who received intensity-modulated radiation therapy were divided into three groups according to the peripheral blood hemoglobin concentration before radiotherapy（HBC120 g/L,HBC 120～150 g/L and HBC≥150 g/L）.Results The 3 year local control rates（L-FFR） were 92.9%,94.6% and 93.2%;the distant metastasis-free survival rates（FDM） were 92.9%,85.1% and 90.0%;the disease-free survival rates（DFS） were 64.3%,76.4% and 86.4% and the overall survival rates（OS） were 78.6%,83.8% and 94.3% in three groups respectively.By means of Cox regression analysis,the results demonstrated that the pre-radiation hemoglobin level was the independent factor on the prognosis of patients with nasopharyngeal carcinoma（NPC）after radiotherapy.Conclusion The HBC≥150 g/L is the independent factor that can affect DFS and OS on the prognosis of patients with nasopharyngeal carcinoma（NPC）.

关 键 词：鼻咽癌 放射治疗 血红蛋白 预后 

分 类 号：R739.63[医药卫生—肿瘤]