吉西他滨/长春瑞滨对Ⅲ～Ⅳ期非小细胞肺癌的放射增敏作用  

The Radiosensitizing Effect of Gemcitabine or Navelbine on Stage Ⅲ～Ⅳ Non-small Cell Lung Cancer

作　　者：高春玲[1,2] 王笑良[1,2] 吴晓安[1,2] 叶性景[1,2] 程小峰[1,2] 陈建清[1,2] 

机构地区：[1]厦门大学附属成功医院 [2]解放军第174医院,361003

出　　处：《实用癌症杂志》2012年第1期48-51,共4页The Practical Journal of Cancer

基　　金：南京军区医学科技创新资助项目(编号:08MA069)

摘　　要：目的探讨放疗联合吉西他滨/长春瑞滨治疗晚期非小细胞肺癌的近期疗效及不良反应。方法 27例Ⅲ～Ⅳ期非小细胞肺癌(non-small cell lung cancer,NSCLC),分为2组,其中吉西他滨组12例和长春瑞滨组15例。放疗前均先给予2个周期"紫杉醇+顺铂"方案诱导化疗,紫杉醇135 mg/m2静脉滴注第1天,顺铂30 mg/m2静脉滴注第1～3天,21天为1个周期。放疗同期予吉西他滨300 mg/m2,第1、8、15、22天,或长春瑞滨20 mg/m2,第1、8、15、22天。放疗均采用三维适形方式。结果完全缓解率(CRR)、部分缓解率(PRR)及总有效率(ORR)分别为3.7%(1/27)、55.6%(15/27)和59.3%(16/27)。其中长春瑞滨组和吉西他滨组CRR、PRR及ORR分别为6.7%(1/15)和0、60.0%(9/15)和50.0%(6/12)、66.7%(10/15)和50.0%(6/12)。肺、食管及血液毒性均未出现严重损伤,27例患者均顺利完成放疗。结论放疗联合吉西他滨/长春瑞滨治疗Ⅲ～Ⅳ期非小细胞肺癌近期疗效较好,不良反应均能耐受。远期疗效有待进一步随访。Objective To evaluate the clinical effect and toxicity of concurrent gemcitabine（GEM） or navelbine（NVB） chemotherapy and radio——therapy for stage Ⅲ～Ⅳ non-small cell lung cancer（NSCLC）.Methods 27 cases of stage Ⅲ～Ⅳ NSCLC were treated with concomitant gemcitabine or navelbine and radiotherapy,there were 12 patients in GEM group and 15 cases in NVB group.The induction chemotherapy consisted of 2 cycles of paclitaxel and cisplatin,paclitaxel with a dose of 135 mg/m2 d1 and cispl——atin with a dose of 30 mg/m2 d1～3,21 days was a cycle.27 patients were received three-dimensional conformal radiation therapy combined with gemcitabine 30 mg/m2 or navelbine 20 mg/m2 once a week for four weeks.Results The complete remission rate（CRR）,partial remission rate（PRR） and overall response rate（ORR） were 3.7%（1/27）,55.6%（15/27）and 59.3%（16/27）,respectively.The CRR,PRR and ORR of the NVB group and GEM group were 6.7%（1/15） and 0,60.0%（9/15） and 50.0%（6/12）,66.7%（10/15） and 50.0%（6/12）,respectively.The toxicity of lung,esophagus and blood in 27 patients were well tolerated and all patients completed their treatment successfully.Conclusion The radiotherapy combined with gemcitabine or navelbine for stage Ⅲ～Ⅳ non-small cell lung cancer showed better effect and tolerable toxicity.We would further follow up the long-term result of 27 cases.

关 键 词：肺肿瘤 非小细胞肺癌 吉西他滨 长春瑞滨 放射增敏 同期放化疗 

分 类 号：R734.2[医药卫生—肿瘤]